I have chronic back pain, lupus, and fibromyalgia. Needless to say, lots of day to day pain in my life! This is the only topical product I've found that actually works and doesn't make the pain with a hot/cold feeling. Five minutes after putting this on, whether on my back, hands, feet, knees etc., I can feel the pain getting better. With the levels of pain I have daily, it's not going to take it all away, but nothing does that. However, Penetrex can be the difference between me getting some sleep or laying awake for hours on end. With the 1-10 pain scale, Penetrex can take my pain down one level, maybe slightly more, when I use it as directed. That one level can let me live my life a little more normally, and I'll forever be a customer of Penetrex simply because it works