Tylenol® PM Extra Strength Caplets


4.5 out of 5 stars
  • 5 Stars67%
  • 4 Stars23%
  • 3 Stars8%
  • 2 Stars2%
  • 1 Star1%
4.54 / 5 based on 1,518 Reviews


Relieves minor aches and pains while helping you fall asleep and is non-habit forming when used as directed.

Active ingredients (in each caplet)

Acetaminophen 500 mg
Diphenhydramine HCl 25 mg


Pain reliever
Nighttime sleep aid

Inactive ingredients

carnauba wax, crospovidone, FD&C blue no. 1 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, povidone, pregelatinized starch, sodium starch glycolate, stearic acid, titanium dioxide.


temporary relief of occasional headaches and minor aches and pains with accompanying sleeplessness.


Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take

  • more than 4,000 mg of acetaminophen in 24 hours
  • with other drugs containing acetaminophen
  • 3 or more alcoholic drinks every day while using this product.

Allergy alert: acetaminophen may cause severe skin reactions. Symptoms may include:

  • skin reddening
  • blisters
  • rash

     If a skin reaction occurs, stop use and seek medical help right away.

  • Do not use
  • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
  • with any other product containing diphenhydramine, even one used on skin
  • in children under 12 years of age
  • if you have ever had an allergic reaction to this product or any of its ingredients

Ask a doctor before use if you have

  • liver disease
  • a breathing problem such as emphysema or chronic bronchitis
  • trouble urinating due to an enlarged prostate gland
  • glaucoma

Ask a doctor or pharmacist before use if you are

  • taking the blood thinning drug warfarin
  • taking sedatives or tranquilizers

When using this product

  • drowsiness will occur
  • avoid alcoholic drinks
  • do not drive a motor vehicle or operate machinery

Stop use and ask a doctor if

  • sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of serious underlying medical illness.
  • pain gets worse or lasts more than 10 days
  • fever gets worse or lasts more than 3 days
  • redness or swelling is present
  • new symptoms occur

     These could be signs of a serious condition.

If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children.

Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222). Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.


  • do not take more than directed (see overdose warning)

adults and children 12 years and over

  • take 2 caplets at bedtime
  • do not take more than 2 caplets of this product in 24 hours

children under 12 years

do not use

see more...

Top Questions See all 14 Q&A

Tylenol® PM Extra Strength Caplets
Tylenol® PM Extra Strength Caplets
Reviews (1518)
Q&A (3)
Media (4)
Buy on Amazon
Geneva C.
3 reviews
When I get those pounding headaches these are my go to. I have a high tolerance so I need extra strength. With a high dose. And this does the trick. 
Katherine O.
147 reviews
This.product is amazing. But you have to be careful, only use it at night, like the box said.... you are going to love it
victoria l.
Olive Branch
4 reviews
Wonderful product! Well worth the money!! Being that I am allergic to almost every medicine for pain or sickness I always resort to Tylenol and I am never disappointed!!! Thanks Tylenol for your amazing product!
Devon D.
Winnipeg, MB
47 reviews
Works great! Usually getting quick relief from aches and pains. Purchased at local drug store.
Grace H.
Clear Lake
73 reviews
Works as it says it does. Relieves pain and helps sleep. Great product overall. Would recommend
Izza D.
114 reviews
Always my go to for any headaches, pain or sinus issues or fevers. Tylenol is extremely effective, great price, great options and I recommend it to everyone
Aaliyah A.
296 reviews
Great product, great quality. Releves the pain quickly. Easy to swallow. I would recommend it.
Migail M.
6 reviews
Worked Wonders!!!! For me and I got some needed sleep as well as my headache going away and not coming back in the morning.  If you get really bad headache this is for you. And who doesn't love getting that much needed sleep..
Christele J.
27 reviews
It works great when I have a headache or sore muscles. It’s the only brand I can take with my high blood pressure and I never had an issue with it
Ana C.
Elizabeth, NJ
74 reviews
I tend to get ready bad headaches sometimes right before bed time. This is the only pill that helps me go to sleep when I have those headaches.
Prianka A.
237 reviews
Does it leave hang over of pills in morning .
Prianka A.
237 reviews
How many pills have to take for one dose.
Imani G.
Commerce, TX
87 reviews
Do they have a gel kind?

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