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Tylenol® Extra Strength Caplets for Adults

BY TYLENOL #42 in Pain Relief

4.5 out of 5 stars
  • 5 Stars67%
  • 4 Stars25%
  • 3 Stars6%
  • 2 Stars1%
  • 1 Star1%
4.56 / 5 based on 5,417 Reviews


Get back to the things you love with powerful relief of tension headaches, back pain and more.

Available as caplets. For adults and children 12 years and older.

Active ingredient

Acetaminophen 500 mg (in each caplet)


Pain reliever/fever reducer

Inactive ingredients

carnauba wax*, corn starch*, FD&C red no. 40 aluminum lake, hypromellose, magnesium stearate, modified starch*, polyethylene glycol*, powdered cellulose, pregelatinized starch, propylene glycol, shellac, sodium starch glycolate, titanium dioxide
contains one or more of these ingredients


carnauba wax, crospovidone, FD&C red no. 40 aluminum lake, hypromellose, magnesium stearate,  microcrystalline cellulose, polyethylene glycol, polysorbate 80,  povidone, pregelatinized starch,  propylene glycol, shellac glaze, sodium starch glycolate, stearic acid, titanium dioxide.


  • temporarily relieves minor aches and pains due to:
  • the common cold
  • headache
  • backache
  • minor pain of arthritis
  • toothache
  • muscular aches
  • premenstrual and menstrual cramps
  • temporarily reduces fever


Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take

  • more than 4,000 mg of acetaminophen in 24 hours
  • with other drugs containing acetaminophen
  • 3 or more alcoholic drinks every day while using this product

Allergy alert: acetaminophen may cause severe skin reactions. Symptoms may include:

  • skin reddening
  • blisters
  • rash

If a skin reaction occurs, stop use and seek medical help right away.

Do not use

  • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
  • if you are allergic to acetaminophen or any of the inactive ingredients in this product

Ask a doctor before use if you have liver disease

Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin

Stop use and ask a doctor if

  • pain gets worse or lasts more than 10 days
  • fever gets worse or lasts more than 3 days
  • new symptoms occur
  • redness or swelling is present

These could be signs of a serious condition.

If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children.

Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.


  • do not take more than directed (see overdose warning)

adults and children 12 years and over

  • take 2 caplets every 6 hours while symptoms last
  • do not take more than 6 caplets in 24 hours, unless directed by a doctor
  • do not take for more than 10 days unless directed by a doctor

children under 12 years

ask a doctor

see more...

Top Questions See all 4 Q&A

Tylenol® Extra Strength Caplets for Adults
Tylenol® Extra Strength Caplets for Adults
Reviews (5417)
Q&A (2)
Media (38)
  • "I get headaches more than I'd like to, so I just take one and I will start to feel better after a bit." in 1 review
Emma T.
299 reviews
I love using Tylenol for my pain relief needs! I take 2 Tylenol pills almost daily and it helps relieve my chronic back pain. I can rely on it taking away the pain and I never have to reach for more than the recommended dose. It is affordable and effective.
Darcie P.
Pocatello, ID
4 reviews
Works well and is reasonably priced. Works better for certain things than other. It works worse for certain things compaired to ib profin. We have this as well as childrens tylenol on hand at all times. It is a staple in our medicine cabinet. I would recommend eveyone has a bottle in their homes.
Holly H.
396 reviews
Wellness Guru Expert Level 1
I often have TMJ headaches, along with elbow joint pain. I take two to three tablets when I am in a good amount of pain and within twenty to thirty minutes the Tylenol starts helping relieve the pain noticeable enough for me to fall asleep at bedtime. I keep a bottle in my purse and car, as well.
Mali L.
Memphis, TN
84 reviews
Quick! I really have to watch myself. I’ve learned that if I just take one then wait for like an hour or so the pain is usually gone! I use to take two no matter what it was, but you don’t really have to with this medication. Just take one and you can always layer per box directions if need be.
Jinal B.
Warminster, PA
28 reviews
Tylenol® Extra Strength Caplets for Adults has always come in handy when it comes to pain killer. It has been a life saver for me and has helped me so much with my pain. It’s definitely recommend if the pain is unbearable. It’s my go to over the counter pain relief medication.
Frangely T.
Miramar, FL
103 reviews
I'm not a big pill taker when it comes to pain relief, but when I have a headache that's leaning towards being a migraine, I reach for these. They help fade the pain away without making me feel like dozing off. I also like this form because it will dissolve quicker than the ones with the coating.
Venus L.
433 reviews
Tylenol works great for my headaches and I truly recommend it for people that tend to have them often ! I have not had any bad side effects but I still think you should ask your doctor before taking them !
Britt Britt D.
San Antonio, TX
72 reviews
Tylenol is a must have in my home!! I have extremely bad back problems and nothing works not ever RX medicine!! I pop a few of these and I am up and moving again in no time. My mom who has arthritis and is about to have a knee replacement swears by Tylenol.... Nothing works better!!!
Purnima D.
232 reviews
Wellness Guru Expert Level 1
I don’t like drugs. I can’t even take medicine. But once I had cramps and I had no choice because the suffering was too much. I gave into Tylenol and MY PAIN WAS GONE. I haven’t had cramps for five months after taking that for the first time in my life! I would recommend to others as well.
Lauren H.
126 reviews
Due to stomach ulcers, I can’t take ibuprofen anymore. I have pain and headaches so I need something I can take occasionally. I keep Tylenol around for that reason. It works well and my stomach problems haven’t returned. It also helps with menstrual cramps as well luckily. 
Leidy daliza R.
Doral, FL
208 reviews
Wellness Guru Expert Level 1
Do you like this product??
Amber M.
Zanesville, OH
1275 reviews
Wellness Guru Expert Level 4

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Tylenol® Extra Strength Caplets for Adults
Tylenol® Extra Strength Caplets for Adults