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Tylenol® Extra Strength Caplets for Adults

BY TYLENOL #42 in Pain Relief

4.5 out of 5 stars
  • 5 Stars67%
  • 4 Stars25%
  • 3 Stars6%
  • 2 Stars1%
  • 1 Star1%
4.56 / 5 based on 5,417 Reviews


Get back to the things you love with powerful relief of tension headaches, back pain and more.

Available as caplets. For adults and children 12 years and older.

Active ingredient

Acetaminophen 500 mg (in each caplet)


Pain reliever/fever reducer

Inactive ingredients

carnauba wax*, corn starch*, FD&C red no. 40 aluminum lake, hypromellose, magnesium stearate, modified starch*, polyethylene glycol*, powdered cellulose, pregelatinized starch, propylene glycol, shellac, sodium starch glycolate, titanium dioxide
contains one or more of these ingredients


carnauba wax, crospovidone, FD&C red no. 40 aluminum lake, hypromellose, magnesium stearate,  microcrystalline cellulose, polyethylene glycol, polysorbate 80,  povidone, pregelatinized starch,  propylene glycol, shellac glaze, sodium starch glycolate, stearic acid, titanium dioxide.


  • temporarily relieves minor aches and pains due to:
  • the common cold
  • headache
  • backache
  • minor pain of arthritis
  • toothache
  • muscular aches
  • premenstrual and menstrual cramps
  • temporarily reduces fever


Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take

  • more than 4,000 mg of acetaminophen in 24 hours
  • with other drugs containing acetaminophen
  • 3 or more alcoholic drinks every day while using this product

Allergy alert: acetaminophen may cause severe skin reactions. Symptoms may include:

  • skin reddening
  • blisters
  • rash

If a skin reaction occurs, stop use and seek medical help right away.

Do not use

  • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
  • if you are allergic to acetaminophen or any of the inactive ingredients in this product

Ask a doctor before use if you have liver disease

Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin

Stop use and ask a doctor if

  • pain gets worse or lasts more than 10 days
  • fever gets worse or lasts more than 3 days
  • new symptoms occur
  • redness or swelling is present

These could be signs of a serious condition.

If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children.

Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.


  • do not take more than directed (see overdose warning)

adults and children 12 years and over

  • take 2 caplets every 6 hours while symptoms last
  • do not take more than 6 caplets in 24 hours, unless directed by a doctor
  • do not take for more than 10 days unless directed by a doctor

children under 12 years

ask a doctor

see more...

Top Questions See all 4 Q&A

Tylenol® Extra Strength Caplets for Adults
Tylenol® Extra Strength Caplets for Adults
Reviews (5417)
Q&A (2)
Media (38)
  • "I get headaches more than I'd like to, so I just take one and I will start to feel better after a bit." in 1 review
Kyndall M.
Sidney, NE
390 reviews
Wellness Guru Expert Level 1
I get headaches often so I always take a Tylenol. I choose Tylenol because it’s the safest one to take and it works really well! I’ve always stuck to Tylenol because it’s effective!
Jamie P.
Jonesboro, AR
20 reviews
I was diagnosed with bloodclots a while back. With the thinners I was using, I was only allowed Tylenol. It always did the job then, so I never felt the need to try anything else.
Rossalynn D.
Tucson, AZ
137 reviews
Great pain med to use for headaches, cramps, fever, etc. You can take on an empty stomach with no problem. Always at a good price too. One of my go-to pain meds.
Melissa D.
Henrico, VA
12 reviews
Super effective!! I keep these in store for my seasonal headaches, and they relieve the pain quickly. They're also easy to take without water, which is sometimes necessary for me.
Erin G.
Metairie, LA
18 reviews
I use these sometimes but I do believe that other products work better for me. I use this a lot when I don't have the other medicines but in a crunch these work very well. I keep a couple of them in my purse with me if I run out of others!
Deosha A.
Philadelphia, PA
209 reviews
I love using the extra strength tablets because sometimes when I come from the gym and I am sore or when my head hurts I take these and lay down for a quick nap. I recommend these
Gabriella R.
164 reviews
I feel like the older I get the less stronger they get as well. I could take two of these and still have a headache hours later. Sometimes they do work depends on how they feel.
Amanda H.
134 reviews
This is my go to for pain relief. It is not to pricy and it works well it may not be the fastest to kick in but it always worse and it is safe whail breast feeding my little one
Valerie C.
12 reviews
I suffer from frequent migraines and I also have to be careful about not taking nsaids. This is the best thing for my migraines. I usually have to take two but it allows for the pain to go away long enough for me to relax and get some sleep.
Sharman G.
Lost Creek, WV
60 reviews
My lord and savior when I’m in pain of any kind! Tylenol is about the only over the counter pain reliever I can take that relieves my pain effectively but doesn’t make me drowsy.
Leidy daliza R.
Doral, FL
208 reviews
Wellness Guru Expert Level 1
Do you like this product??
Amber M.
Zanesville, OH
1275 reviews
Wellness Guru Expert Level 4

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Tylenol® Extra Strength Caplets for Adults
Tylenol® Extra Strength Caplets for Adults