Thorne Research PharmaGABA-250 - 60 Vegetarian Capsules Gamma-aminobutyric acid (GABA) is a major neurotransmitter widely distributed throughout the central nervous system. Because too much excitation can lead to irritability, restlessness, sleeplessness, and spasmodic movements, this excitation needs to be balanced with inhibition. GABA - the most important inhibitory neurotransmitter in the brain - can provide this inhibition, acting like a brake during times of runaway stress. In addition, studies also indicate GABA can promote relaxation and enhance sleep. It is thought that either low GABA levels or decreased GABA function in the brain may have an adverse impact on neurological health. Stress is a normal part of life. Job pressures, family contention, financial insecurity, traffic, and time management are just a few of the stressors we are faced with on a daily basis. For some people, the effects can be overwhelming, leading to feelings of nervousness. Managing stress can exert beneficial effects on the cardiovascular, immune, and neuroendocrine systems. GABA regulates nervousness by calming excitatory neurotransmitter activity Increased GABA levels improve mental focus and relaxation, without drowsiness In at least one study, natural PharmaGABA decreased signs of stress; synthetic GABA did not The natural GABA in Thorne's PharmaGABA-250 is produced via a fermentation process that utilizes Lactobacillus hilgardii, the bacteria used to ferment vegetables in the preparation of the traditional Korean cabbage dish known as kimchi. Clinical studies show this natural form of GABA can increase the production of alpha-waves in the brain, creating a profound sense of physical relaxation while maintaining mental focus. In contrast, the stress-related beta-waves in the brain are decreased.