I had tried literally everything, including ProActiv, when I tried Unblemished. Immediately, my skin felt much healthier and i could already see improvements in my TERRIBLE acne. The medicines used in it are different than Pro Activ even though they are made by the same people. As far as over the counter types, this face wash is made by doctors, so its just like having a face wash prescribed to you without going to the doctor or derm. I love this product and it is definitely worth it!