SAMe (F) is available by Progressive Labs. PL? Since 1972 SAMe Dietary Supplement 200 mg. S-Adenosyl-Methionine Enteric Coated 30 TABLETS More Info: SAMe is produced in the liver from the amino acid methionine. I n the body, SAMe functions as a methylation agent, transferring methyl groups between molecules. SAMe is the most effective of all methyl donors. It participates in 35-40 essential biochemical processes including detoxification reactions and manufacture of brain chemicals, antioxidants and joint tissue structures. Folic acid and vitamin B-12 are necessary for the synthesis of SAMe, and deficiencies of these vitamins result in low concentrations of SAMe in the central nervous system (CNS). Low blood or CNS levels have been detected in people with cirrhosis of the liver, coronary heart disease, Alzheimer s disease and depression. SAMe has been effectively used as an anti-depressant; it is beneficial for disorders of the joints and connective tissues, such as osteoarthritis and fibromyalgia; it promotes the health of the liver; and it may lower homocysteine levels, an amino acid acid associated with cardiovascular disease.