Dietary Supplement. The Original SAMe™ S-Adenosyl-Methionine Clinically Shown to Maintain: Mood Emotional Well-Being*. Joint Health & Mobility*. Liver Function & Health*. The Only Time-Proven Form of SAMe SAMe is found in every living being. It is an important physiological agent synthesized by the body, and it is involved in over 40 biochemical reactions, some of which effect: Mood - SAMe & Emotional Well-Being SAMe is essential to the manufacture of many important b.