I used to take Culturelle, but the cost was just too high for a 30 day supply for a probiotic that worked, but not great. So I did my research to find something to replace it. Thats when I found the Now Probiotics. It works AMAZING, way better the Culturelle ever worked for me. I definitely notice a difference. For people who say "it doesn't work" and gives it a bad rating, its probably just not the right probiotic for THEM!