Compare to the active ingredient in Nicorette® Lozenge. Up & up™ Nicotine 4 mg Stop Smoking Aid Mint Lozenge - 216 Count, is part of a Nicotine Replacement Therapy. Nicotine Replacement Therapy (NRT) is designed to wean your body off cigarettes. It helps regulate, control and gradually reduce your body's cravings for nicotine. If you smoke your first cigarette within 30 minutes of waking up, use Nicotine Polacrilex Lozenge, 4 mg. If you smoke your first cigarette more than 30 minutes after waking up, use Nicotine Polacrilex Lozenge, 2 mg. Up & up products are subject to the same manufacturing standards mandated by the FDA, just like. Age Group: Adult.