I've never had a breakout after using these. That said, I only use these to remove makeup. I work for a dermatologist and they don't recommend using these in place of washing your face. These wipes are fantastic for taking on overnights when you just want to wipe your face off and go to bed, but you still need to wash your face with some kind of soap or face wash the next day. I highly recommend Nuetrogena Oil Free Acne Wash. It's gentle enough for all skin types, but really does a deep clean of your face! I use that and a moisturizer and I get so many compliments on my skin. It really is the best stuff.