Neutrogena® Ageless Intensives® Anti-Wrinkle Deep Wrinkle Serum


4.0 out of 5 stars
  • 5 Stars45%
  • 4 Stars27%
  • 3 Stars17%
  • 2 Stars6%
  • 1 Star5%
4.01 / 5 based on 437 Reviews



Our fast-absorbing retinol and multi-vitamin formula is clinically proven to deliver noticeable results. You’ll see a reduced appearance of wrinkles such as crows feet, deep forehead wrinkles, as well as under eye and laugh lines, in just two weeks!

How does it work? The serum’s multi-vitamin complex boosts skin with anti-oxidants to help neutralize skin-damaging free radicals for healthier looking skin.

  • Dermatologist Tested
  • Allergy tested
  • Non-comedogenic (won't clog pores)


  • Apply once a day to clean skin.
  • Dispense one drop onto fingertips.
  • Smooth over entire face, focusing on wrinkle-prone areas.
  • To maintain formula efficacy, turn pump to "closed" position (left) after every use.
  • If you have sensitive skin, use every other day for 1 to 2 weeks, working up to daily use.

You may experience mild redness, a warm, tingling sensation or flaking (skin exfoliation). These are normal, temporary indications that the formula is working. If effects persist or cause discomfort, limit use to once every 2 to 3 days until your skin adjusts, then revert to daily use.


Water, Cyclopentasiloxane, Dipropylene Glycol, Dimethicone, Isononyl Isononanoate, Adipic Acid/Diglycol Crosspolymer, Dimethicone/PEG-10/15 Crosspolymer, Dimethicone/Vinyl Dimethicone Crosspolymer, Squalane, Glycerin, Bisabolol, Ethylhexylglycerin, Sodium Chloride, Caprylic/Capric Triglyceride, Sodium Citrate, Erythrobic Acid, Dipotassium Glycyrrhizate, BHT, Retinol, Tocopherol, Avena Sativa (Oat) Kernel Extract

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Top Questions See all 7 Q&A

  • Would this work for combination sensitive skin?3 Answers
  • This product seems to be working but it burns like crazy ...2 Answers
Neutrogena® Ageless Intensives® Anti-Wrinkle Deep Wrinkle Serum
Neutrogena® Ageless Intensives® Anti-Wrinkle Deep Wrinkle Serum
Reviews (437)
Q&A (2)
Media (7)
pam l.
12 reviews
This is the absolute best drugstore retinol! This is way better than their "rapid" line. It is a true serum (not one of the many that say serum on the package, but they are more like a cream). It is strong, and makes a real difference on the skin! For new users, or sensitive skin, it will have a purging period (flaking.. etc). If you tough it out, you wont be sorry! That's cell turnover, and means it's working.
Shaynie C.
Cleveland, OK
18 reviews
I enjoy this serum a lot! It’s extremely moisturizing and little goes a very long way. It does contain a retinol so if you’ve never used one before, I would suggest only using this product once every other day or maybe even once every couple of days, depending on how sensitive your skin is. Initially it does feel a bit unpleasant, but over time, you get used to it and can work your way up to daily use! I don’t have deep wrinkles, but still love this product a lot! Be sure to use a facial sunscreen if you decide to try this one out!!
Kaitlyn G.
Jonesboro, AR
28 reviews
Beauty Junkie Expert Level 1
This serum is a little heavy, however, it does its job! I bought this item twice until I discovered the Hydro Boost serum. The packaging was extremely nice. I would buy this product again if the Hydro Boost serum was out of stock.
Angie G.
188 reviews
Beauty Junkie Expert Level 4
I started using this a few weeks ago and like all retinol products, it did dry out my skin a little, but it recovered fast. I like that it's almost scentless and is quickly absorbed. I've seen a difference in my forehead lines, but I don't think it did anything for my smile lines. I'll keep using it until I run out and will decide if I'll repurchase then.
Shelly W.
Myrtle Beach
301 reviews
Beauty Junkie Expert Level 3
I had high hopes for this product when I heard that I would l see results in as little as two weeks.  I personally did not notice any difference at all and I have been using it for well over a month.  I'm giving it three stars because it didn't break out o otherwise negatively effect my skin.  I do like pump bottle it comes in.
Nicki M.
64 reviews
Beauty Junkie Expert Level 1
I applied this once at night and the next day m y face was a dry, flaky mess. It had actually burned my skin. Eventually, my skin got used to the retinol and stopped burning. However, at that point I had run out of the product. I didn't see any reduction in wrinkles or acne, but am not sure if continued use would be more effective.
Liz S.
Arlington Heights
15 reviews
Beauty Junkie Expert Level 1
This product smells amazing and really does the trick on my fine smile lines! They're hardly there anymore! It is not an overnight miracle worker, but if applied consistently, you will begin to see results. I apply this every morning and it has become my favorite addition to my skincare routine!
Jazmine M.
Mission, TX
243 reviews
Beauty Junkie Expert Level 3
I like this product for under my eyes. I have so wrinkles there and I hate it. This product really helps when I'm using concealer under my eyes. So i put the cream, concealer, then set my under eyes. It's not as expensive as something you would find in sephora. I love neutrogena products. 
Megan M.
Oak Ridge
376 reviews
Beauty Junkie Expert Level 4
So once again, another 5 star Neutrogena skin care product. I've used other retinol products, most more expensive and this is by far my favorite. It is affordable at a little more than $20 and it's a decent sized bottle of serum that goes a long way so it's an even better bargain because of that. It's effective and as powerful and quality as more high-end skincare retinol products. I bought this at Walgreens where you can usually always find coupons online for Neutrogena and earn rewards points too ( I bought a new bottle today and had a 4 dollar off coupon, plus store had b1g1 50%off so I got 2 skincare products for less than 35$ so always check the sale products there) This is a retinol so sensitivity can occur if you aren't used to retinol products. I've used retinol for a while now and I have no sensitivity anymore. Decrease amount by half and decrease usage to every other day if sensitivity occur and continue until skin gets used to product. I use this for my crows feet and laugh lines and almost instantly, within a few days I noticed a smoothing to them. My face in general, looked tighter and smoother. It was a noticeable difference, not just by me, but my husband noticed a difference in my skin calling me "young and radiant" which pleased me more than he knows. I use this in combination with a vitamin c product and Neutrogena® Hydro Boost Multivitamin Booster every night prior to moisturizing and sleeping cream are applied. My skin looks hydrated, healthy and has a youthful glow that I've been trying to achieve. This touches the lines around my eyes so I don't have to settle for a anti aging eye cream when I need a hudrating cream more for my dry under eye skin. This is my main anti aging serum and at almost 40, the few lines I had are barely there and I look so much younger than I am. It makes me confident and feeling more attractive and I think that's the point of all the work I put into my skincare routine. My goals are to look young, radiant and pretty and this is definitely a product that helps me achieve my goals. I recommend it for anyone wanting an affordable, effective product that will give you results in a short time period and gives lasting long term results
Mandie S.
2 reviews
I love this product and use it every day and night. When I can't afford something, this is the perfect go-to because it is reasonably priced and works well. I have been buying this product for years and years now, and will continue to do so for all the years to come!
Marissa V.
Fredericksbrg, VA
22 reviews
Would this work for combination sensitive skin?
Jill L.
3 reviews
This product seems to be working but it burns like crazy for the first few minutes after applying it.  Should I stop using this or use less product or less often ?

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