New Softgels Dietary Supplement. Lowers Cholesterol* Reduces Both Dietary & Genetic Cholesterol Nature Made CholestOff Complete® combines esterified Reducol, a proprietary blend of plant sterols and stanols and pantesin. CholestOff Complete reduces both dietary and genetic cholesterol.*. Reducol lowers cholesterol by reducing the absorption of dietary cholesterol into the bloodstream*. Pantesin lowers genetic cholesterol by reducing the production of LDL cholesterol in the liver* Before taking CholestOff Complete dietary cholesterol is absorbed into the bloodstream. After taking CholestOff Complete.