Great for Hot-Spot & Itch Relief. Natural Shampoo with Neem, Tea Tree Oil & Echinacea. For Dogs of All Ages. Made with Natural Ingredients Natural Chemistry s Triple Treatment Shampoo is formulated with ingredients proven effective against dermatological conditions such as mange, hot spots, and pyoderma caused by gram positive bacteria, fungi, and yeast. Neem, Tea Tree Oil, & Echinacea Combine to Provide Effective Treatment of Minor Dermatological Conditions. No Added Artificial Perfumes or Fragrances to Irritate Sensitive.