MSM 500mg Glucosamine 375mg by Natural Factors 90 Capsule An excellent combination of nutritional joint support and pain relief. Natural Factors' superior remedy for painful joints and connective tissue contains a combination of MSM (Methyl-sulfonyl-methane) and Glucosamine Sulfate. This combination works to maintain the structural integrity of joints and connective tissue while it jumpstarts the healing process. Glucosame Sulfate and Chondroitin protect the cartilage and connective tissue and optimize joint function. MSM is a powerful nontoxic therapeutic agent that inhibits pain impulses lessens inflammation increases blood supply reduces muscle spasms and softens scar tissue.