Dietary Suppplement. Life Extension Optimized Saffron with Satiereal is a satiety dietary supplement mostly derived from saffron. It helps reduce snacking between meals by helping regulate serotonergic receptors that induce satiety. Life Extension Optimized Saffron with Satiereal is mostly derived from saffron. Saffron is a well-known spice originally found in Asia. It has long been used not only for cooking, but also for perfumes, flavoring, and therapy. Ancient cultures primarily used saffron as a stress-reliever and mood-enhancer. The standardized versions of these saffron extracts are now used for weight loss purposes. It primarily acts as an appetite-suppressor by eliminating food cravings, resulting in less food consumption. By taking Life Extension Optimized Saffron with Satiereal, there is.