Anti-Viral. Kleenex® Anti-Viral facial tissues have three soft layers, including a moisture-activated middle layer that kills 99.9% of cold and flu viruses. Because cold and flu viruses are often spread by hand contact, Kleenex® Brand has developed a tissue for your whole family. Kleenex® Anti-Viral tissue has three soft layers, including a moisture activated middle later that kills 99.9% of cold and flu viruses* in the tissue within 15 minutes. This product has not been tested against bacteria, fungi or other viruses. See below for anti-viral* details. 68 3-ply tissues; 8.2 x 8.2 in. (20.8 x 20.8cm).