My mom used this on me and my siblings. Never had any problems. I still use it on my thigh when they rub together. And you can also put it in your hair and it acts like a dry shampoo. We never had any problems. But everybody's chemical makeup is different so your body or your kids body might react differently to it. The only way you can know is to try it.
My daughter was very allergic to a lot of different diaper rash oitments and had very sensitive skin. Best way to use this is an old fashioned remedy: put a thin layer of petroleum jelly with a bit of the powder to alleviate any skin irritation. This was the only thing that would give her any relief!