Jarrow Formulas' pharmaceutical grade, stabilized SAM-e is a full 200 mg elemental SAM-e from 400 mg of SAM-e tosylate disulfate. SAM-e 200 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. SAM-e (S-Adenosylmethionine) is an amino acid derivative that has been clinically proven to benefit brain and joint function. Found in all living cells, SAM-e is also called "activated" methionine (an essential amino acid) since it is formed by the combining of ATP with methionine. SAM-e has undergone dozens of trials involving thousands of patients. Researchers studying the beneficial effects of SAM-e have identified the following benefits of SAM-e 200:Joint StrengthSAM-e supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue, including glucosamine and the chondroitin sulfates, are sulfated by SAM-e metabolites. Brain MetabolismSAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-Dopa, Dopamine and Related Hormones, Epinephrine and Phosphatidylcholine (a component of Lecithin).LiverSAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transferase), which are substances important for liver function. LongevityMethylation of DNA appears to be important in the suppression of errors in DNA replication. Demethylation of DNA is considered a contributor to the aging process. Proper methylation through substances such as SAM-e positively influences longevity.