Product Information from Herb Pharm We prepare our Boneset extract from the leaf & flowering tops of Eupatorium perfoliatum plants which are Certified Organically Grown on our own farm without the use of chemical fertilizers, pesticides or herbicides or are Custom Wildcrafted in their wild native habitat. To assure optimal extraction of Boneset's bioactive compounds, the plants are hand-harvested only when coming into flower, are carefully shade-dried and cleaned of superfluous stems, and are then thoroughly extracted. Our Boneset is never fumigated or irradiated. Directions: Shake well before using. Two to four times per day take 30 to 40 drops in a little water. Ingredients: Boneset extractives (Eupatorium perfoliatum) 1:5, Certified organic grain alcohol (42-46%), Distilled water.