Shake bottle before drinking. Drink entire contents. After 15min drink 160x of water. Wait 45min to be effective. For best results - avoid toxins 48 hours before cleansing; do not drink more than 16oz of water per hour; on the day of cleansing eat and drink normal quantities; if possible schedule cleansing for the afternoon and urinate 3-4 times prior; drink is effective for 45min up to 5 hours - most effective up to 2 hours.