I've been using this for almost a year now. I have gall bladder issues and after a very bad attack of it I needed to take these twice a day for about the first 3 months, then I went down to one a day unless I ate something very spicey, then I took two that day, 12 hours a part. Now I only take one every few days at most so they have definitely let my gall bladder heal and seem to be keeping it in check. I've tried other brands with bad results so I'm sticking witrh these. They also cost the least.