I get blisters very easily, so Moleskin is a must for me. I try to always have some on hand, just in case. This is a generous size, that will last me quite a long time. I cut a small piece, the size and shape of whatever part of the shoe is rubbing, and simple stick it on. It is very sturdy and stays on for a very long time. I've also used Moleskin after cutting off pesky tags to keep whatever is left of the tag from poking out.