Douglas Laboratories Bone CoFactors Osteo Support - 180 Capsules Douglas Laboratories Bone CoFactors is formulated to provide the necessary vitamins and minerals combined with a milk protein called MBP that helps to support bone strength. MBP has the distinctive function of balancing osteoblast and osteoclast activity, which complements the function of other nutrients in Douglas Laboratories Bone CoFactors for optimized bone health. Douglas Laboratories Bone CoFactors is a dietary supplement indicated for individuals that require the nutrients necessary for healthy bone strength and metabolism. FunctionsBones are constantly being remodeled, not only during the growth stages, but also into adulthood. This process of bone turnover involves two types of cells: osteoblasts and osteoclasts. Osteoblasts promote bone formation and create collagen, so that calcium can effectively adhere to the collagen and create new tissue. Osteoclasts destroy old bone tissue by releasing acid and enzymes to dissolve calcium and collagen. However, osteoclasts can become excessive due to hormonal imbalances and other factors, leading to calcium deficiency in the bone. Therefore, nutrients that suppress excess osteoclast activity and support osteoblast activity are important to the health of the bones. MBP is a milk protein that is found in human and bovine milk. It is a highly bioactive fraction of total milk protein content that has been clinically shown to support the formation of healthy bones. Unlike other bone substances such as Vitamin K, MBP increases the number of bone-forming osteoblast cells and regulates the activity of bone-destroying osteoclast cells (see chart, page 2). Therefore, MBP is a multifunctional protein that functions by acting directly and/or indirectly on bone cells to promote the bone formation, while at the same time inhibiting excess bone destruction, called bone resorption.