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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,321 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

see more...

Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10321)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Tracy S.
Ashland, OH
106 reviews
Beauty Junkie Expert Level 1
Woah this stuff does the trick. A little dab of this right on a problem area before bed and the issued area will be gone or greatly reduced in size by the next morning. Down side is it does stain/bleach fabric.
Sadie J.
Sarasota, FL
54 reviews
Beauty Junkie Expert Level 1
I bought this once and fell in love within a good 5-7 days my acne that you could notice was gone this is the product for you if your really trying get rid of acne
Definitely need to restock in it!!!
Abby H.
11 reviews
Gets rid of acne in a week or less. Really helps with blemishes or pimples. It did meet my expectations and I would buy again. It is a gentle product and doesn't cause any other breakouts. I am a first time user and recommend this product to anyone struggling with acne.
Deanna H.
Mize, MS
98 reviews
Beauty Junkie Expert Level 2
This stuff is ok, it helps a little but the smell is kinda strong! And it kinda peels off really easy. It’s not my favorite product, but I would use it again if I needed it. I guess I would recommend this.
tori_rost R.
West Deptford, NJ
32 reviews
Beauty Junkie Expert Level 1
I use this product almost every night. It truly does take away the pimple overnight. Takes away redness and lowers the raise on your face in hours. It’s affordable and you can buy at your local cvs!
Christine C.
Virginia Beach
7 reviews
This is a frequent in my night time routine. Whenever I feel a spot coming on. Takes car of the job but I do feel that sometimes it doesn’t work as quickly as I’d like. But all in al a good product!
Celeste T.
24 reviews
Beauty Junkie Expert Level 1
For acne this is one of the best spot treatments I have ever used. I applied this to my acne that just popped up and overnight it disappeared. I love this product and how effective it was on my skin.
Emily B.
Brooklyn, WI
53 reviews
Beauty Junkie Expert Level 2
I have used this product for some time on any bad acne that I have. I’m not sure how well it works, but I put it on at night, especially if a pimple has just been popped to get the medicine in there.
Brynna H.
Greeley, CO
130 reviews
Beauty Junkie Expert Level 3
This has always been my secret weapon since middle school. Whenever i got a new blemish, i’d apply this right away and it would immediately dry it up and clear it away. Still always a must in my skin care drawer!
Krista B.
Crowley, TX
101 reviews
Beauty Junkie Expert Level 2
This is my absolute favorite spot treatment! If I feel a pimple coming up(first sign) I can put this on and it never breaks through! If I wake up with a spot, I can this on and its gone the next day!
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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