Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,530 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,688 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10530)
Q&A (464)
Media (121)
Buy on Amazon
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Ashton B.
Chicago, IL
46 reviews
Purchased at: Target
This will dry your problem spots right up! Just dab it on before bed and go to sleep and once you wake up the swelling and redness will have subsided! It’s a drugstore product so it’s very reasonably priced which is even better!
Megan R.
Pittsburgh, PA
30 reviews
Beauty Junkie Expert Level 3
Purchased at: Walmart
This product was okay - however, I didn’t notice much in terms of healing the blemish more quickly.
Lisa W.
8 reviews
I use this product any time I have a breakout. It is rare that I do get acne, but when I do this is what I reach for. It's strong, and will peel my face if I use it to excess, but that's not what it's meant for. I only but clean & clear advantage spot treatment for my acne, because I know that it solves any breakouts I have.
May P.
50 reviews
Beauty Junkie Expert Level 3
I repurchased this product twice and I always use it up within a year. I usually get acne near my period so this has been pretty good at either speeding up the life cycle of white heads or getting rid of lingering ones. I do find myself using this pretty frequently throughout the day. Also, I appreciate that the product has a gel consistency that dries matte instead of drying with a white cast like other products. It is pretty good at what it does and it is a staple for me.
Brittney P.
54 reviews
Beauty Junkie Expert Level 1
Purchased at: Rite Aid
This helps greatly for little spots that you notice after showering and wiping make up off.
Denise A.
Las Vegas, NV
36 reviews
Beauty Junkie Expert Level 1
Purchased at: Walmart
This did work and you HAVE to use this every night! It met my expectations and it cleared most of my skin up! I am soo happy I used this and it is so worth the price !! Would buy again. Definitely will go buy some !!
Lindsey K.
11 reviews
Purchased at: Target
This is my go-to drugstore acne spot treatment. I have repurchased this more times than I can count. It will not dry your skin out but it will definitely clear your blemishes. I definitely recommend this product.
Nina E.
110 reviews
Beauty Junkie Expert Level 2
Purchased at: Walmart
Works. If you're having breakouts I suggest you buy this. It stops the breakouts clears up your skin. Would recommend this product
McKenzie F.
8 reviews
I have used this product for the last 6 years and it continues to impress me. It’s apart of my two-a-day face routine and instantly minimizes pores and pimples.
Jess H.
53 reviews
Beauty Junkie Expert Level 1
Purchased at: Amazon
Broke out with some acne a few days before a formal and this was a life saver! Works in just a few days and I will always keep some on hand. Great product, highly recommend. Fair pricing as well is a plus.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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