Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,525 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,688 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10525)
Q&A (464)
Media (121)
Buy on Amazon
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Jana O.
37 reviews
Beauty Junkie Expert Level 1
Purchased at: Walmart
As far as spot treatments go, this product has to be my favorite when trying to prevent aggressive acne spots. The thin nozzle makes it easy to target one small area and this product does a nice job for the most part!
Anndrea C.
15 reviews
Purchased at: Target
This product is Okay. It doesn’t work the best but pretty god for the price. Stings a little when you put it on but that’s how all spot treatments are. It has good packaging but other brands have a better product.
Cameron W.
Charlotte , NC
88 reviews
Beauty Junkie Expert Level 2
Purchased at: Walgreens
I love this formula because it’s light and clear so it can be worn on skin during the day to stop breakout from coming or getting worse. I sometimes even put it under my makeup on my really bad days if I’m not into a no makeup look.
Jillian C.
Amherst, NY
45 reviews
Beauty Junkie Expert Level 1
Purchased at: Target
With this it’s kind of a hit and miss. I do find it works a lot more than doesn’t but it really does depend on the intensity of the pimple. It also helps to was your face on top of using this product. Would recommend.
Elly L.
Anaheim , CA
144 reviews
Beauty Junkie Expert Level 3
Purchased at: ULTA
Perfect for the small pimples that start to come out and it really works. I don’t mind the feeling of it on just spots on my face because to me it’s not too thick
Jenna W.
Fond Du Lac, WI
39 reviews
Beauty Junkie Expert Level 1
Purchased at: Walgreens
This has been my go to acne product for years. I like it so well that I haven’t even tried anything else. It clears my breakouts without drying my skin, and it gets rid of acne spots overnight!
Andrea S.
Orlando, FL
70 reviews
Beauty Junkie Expert Level 1
Purchased at: Walmart
Es un producto que me ayuda a veces no siempre obtengo un buen resultado. Pero como siempre digo cada piel es diferente no es un mal producto a mi hermana le va de maravilla! Si lo recomendaría a base de las experiencias de ella.
Claire F.
14 reviews
Purchased at: Target
This is the best acne spot treatment I have used. My pimples are significantly smaller when I use this product. Although it burns it works really effectively and efficiently and it exceeded my expectations and I have and will continue to buy it again.
Laura P.
Shelby, NC
16 reviews
Beauty Junkie Expert Level 1
Purchased at: Walmart
This acne formula is in a gel form and works really well! It's non irritating and I can tell a difference from one overnight use! The tube lasts quite a while as well.
Estelle H.
8 reviews
Purchased at: Walmart
I absolutely enjoy this product! Clean and Clear has been keeping my skin acne free with this product since years and years ago! I continue to use this product and reach for it every time I’m grocery shopping. A must-have product!!!!
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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