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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,328 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

see more...

Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10328)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Erin M.
9 reviews
Beauty Junkie Expert Level 1
My husband and I both use this every night before bed. I have a few blemishes that occur every now and then and this works wonders for an overnight treatment. My husband breaks out much worse than I do and he loves this!
Jaycelyn K.
Medford, MA
111 reviews
Beauty Junkie Expert Level 4
I bounce between Clean & Clear Advantage Acne Spot treatment and another brand. This cream acne treatment works pretty well, usually within 1-3 days, with minimal irritation. Can dry out the skin too much though.
Allie J.
47 reviews
Beauty Junkie Expert Level 1
I get acne quite frequently. When I use this gel, I notice it helps a bit, but not nearly as much/quickly as my friends claim. It also dries out your skin, so make sure to moisturize well when using it and wear sunscreen.
Dorinda C.
Tampa, FL
124 reviews
Beauty Junkie Expert Level 4
Salicylic acid works best for spot treatment on my combo skin. And my skin is an extreme combo super dry in some spots and super oily in others ( and know it does not balance out ) but this helps with those few breakouts
Alyssa K.
Asheville, NC
50 reviews
Beauty Junkie Expert Level 1
This really does help! It has a lot of the active ingredient in it and I really like it. Just a little tiny bit goes a long way, so it really makes up for the value. I would say though, apply it bare faced and let it dry.
tara k.
86 reviews
Beauty Junkie Expert Level 1
This spot treatment works well when used overnight. I️t helps reduce the appearance of the pimple as well as minimizing any redness that surrounds the area. This product works great. Would recommend to treat harsh pimples
Mimi S.
Los Angeles, CA
16 reviews
Definitely kept my redness down! After the first week of trying it I saw the redness and acne bumps go down. It didn’t eliminate the pimple or bump but it reduced the redness/size! It works better after washing your face!
Makenzie L.
Appleton , WI
2 reviews
After like one or 2 days my blemishes we’re gone, does sting just a tiny bit but that’s how you know it’s working. I clean my face and then put it on before bed and usually after a couple days it’s gone!!! Clean & Clear® Advantage® Acne Spot Treatment
Nicol D.
21 reviews
Beauty Junkie Expert Level 1
Absolute favorite acne spot treatment. I keep it in my purse and can even apply it over makeup and notice a different when I take my makeup off. It works fast and it doesn't sting when I personally apply it.  
Sapphire D.
Vineyard, UT
151 reviews
Beauty Junkie Expert Level 2
This product is simply amazing. If you haven’t tried it you need to! The packaging is nice and i seriously love how gentle it is on my skin. It totally was worth it and I buy this all the time! Definitely give it a try!
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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