Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,541 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,688 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10541)
Q&A (464)
Media (121)
Buy on Amazon
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Savannah J.
Garner, NC
79 reviews
Beauty Junkie Expert Level 2
I’m husband has been using this product for years and I used to roll my eyes and suggest he use some of my higher end products until I developed a huge pimple and sneakily tried this, well much to my chagrin, it worked wonders! I’m now a regular user, this stuff definitely works!
Serenity Cristina V.
South Charleston
6 reviews
Beauty Junkie Expert Level 1
High school was a long time ago, yet I still on occasion have blemish or two. Clean and Clear Spot Treatment is my go to. I always make sure I have a tube of this in my bathroom! It dries up the blemish without drying out my face. 
Kaley J.
Russellville, AR
27 reviews
Beauty Junkie Expert Level 1
I love this drugstore acne spot treatment. It’s very affordable and worked well for me. I would see instant results in less than 24 hours. It’s not too harsh but does have a slight sting when applying directly onto a problem spot. I also really like the smell of it!
Casey B.
oxford, MS
26 reviews
Beauty Junkie Expert Level 2
I love this product. I apply to white heads and under the skin bumps before i go to bed, and i can tell a significant difference when i wake up! i also apply a few times a day if i’m in a hurry to get rid of acne, and it works wonders.
Alexa W.
20 reviews
Beauty Junkie Expert Level 1
Love this spot treatment! i use it every morning and evening on any acne spots after I cleanse. This is combination with a retinol treatment has done wonders for my adult acne. Does burn slightly when you put it on if you have just washed your face but is not over drying. 
allie R.
41 reviews
Beauty Junkie Expert Level 1
I really haven't had much luck with this product. I put it on my pimples overnight and when I wake up they don't look any better. If anything this product just made my skin really dry and flakey. I definitely don't think this product is a good value.
Sydney A.
Lake City, Arkansas
34 reviews
Beauty Junkie Expert Level 1
The spot treatment is the best way to get rid of those pesky pimples. The packaging was very slick and nice. It was very effective! It is valued at what it is worth! No room for improvement! REALLY!
Korinne A.
11 reviews
Beauty Junkie Expert Level 1
I did not enjoy this product. It did not reduce the appearance of the acne at all. I followed the directions and used it for a couple weeks and saw no difference in my acne. I will not buy it again. And I do not recommend this product.
Alura G.
13 reviews
This does not work. I have noticed no difference on any acne spots. It appears to do absolutely nothing and has an awful smell. Would not recommend to others. It left my skin peeling where the spot was which just made my problem worse!
amy s.
Normandy Park , WA
1276 reviews
Beauty Junkie Expert Level 5
I’ve been using this for a long time. It really is nice to just be able to use a tiny bit and focus it just where I need it instead of having to use it all over. It works really well and I notice a huge improvement after just a few uses.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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