Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,544 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,688 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10544)
Q&A (464)
Media (121)
Buy on Amazon
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Meghan j.
28 reviews
Beauty Junkie Expert Level 1
Works very well! I love this so much, I use it along with proactiv and the clean & clear advantage moisturizer. Gets rid of my acne without irritating my skin. Love it! My skin type is oily, for anyone wondering.
Catherine Q.
83 reviews
Beauty Junkie Expert Level 2
This spot treatment got me through college! I’d use it on the big, painful pimples that always formed on my chin and it really did the trick. Super affordable and the scent was nice!
Tanya L.
Howards Grove
9 reviews
This brand works wonders. It quickly dries out the area with pimples and diminishes them within 48 hours. The spot treatment is worth the price; I’m a repeat user of it! No room for improvement on this product.
kayla 👑.
14 reviews
Beauty Junkie Expert Level 1
I like this. My mom recommended it to me instead of putting toothpaste on my face to dry out the pimple. I can say, it does get rid of the pimple and I was amazed. It runs about 6-8$ depending on where you go. Would definitely recommend purchasing if you need to get rid of a problem area quickly
Asia M.
Christiansbrg, VA
29 reviews
Beauty Junkie Expert Level 1
It’s a decent product but doesn’t work like I want it to. It does knockout pimples but it just takes a long time to get them gone. So overall it does work just not very quick. You definitely have to put it on the pimple several times before it’s gone.
aly🌻 D.
9 reviews
This is a miracle! Overnight it will clear or visibly reduce any redness and stubborn spots! It could be a little harsh for sensitive skin because of the salicylic acid but worth it
Carleigh W.
Millsboro, DE
29 reviews
Beauty Junkie Expert Level 1
I usually try to stick to natural skin care products, but this is a product I’d make an exception for. Anytime I have a spot that will just not go away I rush to grab this. I see instant results and it’s gone in about 2-3 days sometimes even sooner.
Ashliegh J.
N Dinwiddie, VA
6 reviews
VERY GOOD QUALITY! Clean & Clear® Advantage® Acne Spot Treatment I used this on my problem spots and I’d put it on before bed and go to sleep and by morning the spots were noticeably smaller. I am a repeat buyer I will buy this again and again.
Travis B.
Bloomsburg, PA
22 reviews
Part of my nightly routine and I rely on this product to treat and any all pimples or break outs I get. It shrinks my break outs and clears them up over night, would highly recommend trying this product for those who frequently have break out areas.
Haley E.
Americus, GA
606 reviews
Beauty Junkie Expert Level 3
This Clean & Clear Acne cream really dried out my skin and made it red. In addition to drying my skin out it burnt. I felt that it was very harsh on my skin. I wouldn’t buy it again.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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