Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #10 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars7%
  • 1 Star4%


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

see more...

Top Questions See all 1,792 Q&A

  • Does this product work?3 Answers
  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (11,768)
Q&A (520)
Media (126)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Esmer G.
Rio Grande City, Texas
34 reviews
i have to say that this product does work. it might take time but it does the job. your acne marks will eventually disappear. it can last maybe less than a month , depending on how many times you use it.
Lori B.
Martinez, GA
83 reviews
Beauty Junkie Expert Level 4
Only ok for my aging skin. Probably works best for younger skin. However we have a need for acne spot treatments for that errant zit that pops up at the most inconvenient time!!!
Amy K.
Neillsville, WI
42 reviews
Beauty Junkie Expert Level 1
I've used this acne treatment in the past and I wasn't impressed. It didn't work whenever I tried to use it and I applied the cream both day and night. It seemed to dry out my skin more than anything else.
Becca S.
Louisville, KY
32 reviews
Beauty Junkie Expert Level 1
I like this product, but it’s not a favorite.
It does diminish blemishes, but not as quickly as other spot treatments I’ve used.
It also doesn’t wear the best underneath of makeup, it leave a film on the skin.
Allison H.
Colorado Spgs, CO
50 reviews
Beauty Junkie Expert Level 1
I used this product for a little bit but it stopped working pretty quickly for me. I noticed change in the beginning but after a week or so the effects weren't as strong. I would not buy this product again.
Brittany K.
113 reviews
Beauty Junkie Expert Level 2
The spot treatment is a fairly reliable product for trouble blemishes that will not go away after a couple days. It works best on whiteheads for me not closed cysts to dry them down faster.
Carolynn R.
Hobart, IN
115 reviews
Beauty Junkie Expert Level 2
I was actually surprised on how well this worked. I'm only giving 4 stars because if you apply this after you tone your face and moisturize it starts to roll of you face. So you'd most likely have to suffer with dry face or deal with the balls of skin this creates
Emily H.
Abilene, TX
63 reviews
Beauty Junkie Expert Level 2
I love this, it takes just a little to cover small spots on your face. A little goes a long way! I put it on at night and in the morning the acne is basically gone! I bought it at Walmart and continue to buy it.
Lyndsay H.
Herrin, IL
41 reviews
Beauty Junkie Expert Level 2
I use this NIGHTLY I have extremely dry skin so I just pat where I’m feeling a pimple coming or already have one and I notice a difference as early as the next day! This is definitely a staple in my skincare
Alixx B.
222 reviews
Beauty Junkie Expert Level 3
My boyfriend turned me onto this product. He's obsessed with it. Whenever we feel a blemish coming on we will put it on. It clears up the worst of acne. My friends all use it now too. It's great for the price.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

Sign up to join our community!

Influenster Cashback
We recorded your visit.
Clean & Clear® Advantage® Acne Spot Treatment

Amazon was opened in another window. If you made a purchase Cash Back will be automatically added to your Ebates account tomorrow.

Please confirm your email.
If you have an existing Ebates account, make sure to enter your Ebates email

6 characters minimum. Password must consist of letters, at least 1 number and 1 special character.