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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,284 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10284)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Mayka L.
Lancaster , PA
78 reviews
Beauty Junkie Expert Level 4
This prodct is good. But I feel like every time I use it, I can't stop using it because they it would break me out more. I guess i have to try it on for a month or so I can see the difference. That's the only downside other than that it works fine
Ashley S.
Tecumseh, OK
5 reviews
This has always worked for me. I've went through so many different acne spot treatments, and THIS is the one that works great. The next day I see almost complete reduction. One more day of use, and it's completely gone. I know everyone's skin is different, but I say this is always a must try.
Tamanna H.
Ashburn, VA
117 reviews
I love this product because it actually works. It reduces the size of the pimple by half the next day. I usually use this before going to bed and if needed during the morning if I don't have to wear makeup. This is a nice formula too because it's clear. I sometimes use powder over it if I have to go out real quick. Not harsh or irritating at all!
Paige M.
Orlando, FL
114 reviews
Beauty Junkie Expert Level 3
My go to spot treatment! I use this in the set and i absolutely love it! I wouldn't say it zaps them away immediately, but it does work pretty fast! The smell could be better, it smells like medication. But i use it at night so it isn't too bad!
Rebecca J.
Shepherdsvlle, KY
103 reviews
I used this product as a teenager and I can't say that I noticed a difference. Honestly, I haven't found a spot treatment out there that actually works. If anyone has any suggestions, I'd love to hear them. I'm almost 30, and I STILL get pimples.
Abigail M.
36 reviews
Beauty Junkie Expert Level 3
This stuff works great its one of my favorite spot treatments iv ever tried. It is a clear gel and you just dot it on any blemishes you have and leave overnight and it dries up my acne
Helen T.
Whitestone, NY
316 reviews
Beauty Junkie Expert Level 4
This is a great product, It is great at helping reduce pimple size and severity. I would only recommend for use at night, as it can be a little harsh and you do get a very slight stinging sensation that does not last long. It is very effective.
Natalie R.
Chicago, IL
235 reviews
Beauty Junkie Expert Level 4
This product is amazing!! I actually bought the whole kit but this one I was able to carry it in my purse at all times! I loved it worked very fast and efficiently. I would defiantly recommend the
Clean & Clear Advantage Acne Spot Treatment.. :)
Jillian M.
Arlington, MA
107 reviews
This has been one of my go to acne fighting spot treatments since I got my first pimple. The formula is fast acting and reliable for tackling those pimples over night! This product acts a long time and really does the trick for those tough ones!
5 reviews
I love this spot acne treatment. I don't have a ton of acne but when I have a breakout I notice it fade literally overnight when using this stuff. IT doesnt dry out my skin and I have combo skin. Can't beat the price and it lasts me a long time:)
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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