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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,282 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10282)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Madison H.
Haubstadt, IN
8 reviews
Beauty Junkie Expert Level 1
This product is amazing at reducing the size pimples. I can put it on before I go to bed and wake up the next morning and barely even see it. It does not dry my skin out and I would recommend this product to others.
Josie E.
Sunnyside , WA
99 reviews
Beauty Junkie Expert Level 3
This product is my go to for zits! Whoever I have a big pimple, I put some of this gel on it twice daily and within 2 days, it's smaller or completing gone! I've used this product for months and I love it! Everyone needs it!!
Bailey G.
14 reviews
This stuff is my life. I use it on any little breakouts I have. I have very dry skin so I don't like to use an all over treatment but this spot treatment is absolutely perfect! There is a bit of a burning sensation but thats how I feel it's really working!
Amanda H.
Raleigh, NC
84 reviews
Beauty Junkie Expert Level 2
I am not a big fan of this product. I used it and it made my skin very irritated. It is very affordable and cheap and can be easily accessed at many stores. Many of my friends have used it/use it but my face does not react well to it. It comes in a tube that is reasonable for spot treatment. 
Adri M.
7 reviews
It is great for those pesky pimples that need a little more help but it’s harsh so don’t use it all over your face. I has a great price and packaging is easy and durable. I would recommend this to others because it’s good for times you really need it.
Caitlin S.
New York
18 reviews
Beauty Junkie Expert Level 1
This was my ride-or-die staple through my teens. I struggled with acne and it did a pretty good job at not really keeping it at bay but at making it somewhat manageable so I wasn't constantly breaking out with new breakouts everywhere. Just a couple around my face. Ain't perfect, but I'll take it.
Bee S.
Georgetown, TX
35 reviews
Beauty Junkie Expert Level 1
This product helped reduce my acne appearance but I could still feel it under my skin. Like when I would get a zit around my cheek area and then apply this - it would flatten out and the redness would fade... but then it would still hurt when I smiled. As if the zit was still there just under my skin.
Sarah S.
Columbia, PA
79 reviews
Beauty Junkie Expert Level 2
On the rare occasion I get a zit, I just put a dot of this on after some toner and the spot is typically gone the next day. On occasion I have to do it for 2 days in a row, but this stuff typically works right away. Affordable and a little goes a long way for me so I don't have to buy it very often
Lorena R.
Los Angeles, CA
68 reviews
My daughter started breaking out recently & I bought this but in a box with other same brand product & it was so worth it it made her pimples smaller & some even when away ! It's a good product it makes big pimples smaller & little pimples disappear
Dragana T.
6 reviews
This is my favorite spot treatment for the drug store! I've been using it for about 6 years and I have repurchased this countless times! It's is defiantly worth the $6ish dollars that you pay for it and I would definitely pay more for it! It is amazing to put on pimple that you just have extracted!
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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