Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,535 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

see more...

Top Questions See all 1,688 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10535)
Q&A (464)
Media (121)
Buy on Amazon
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Sara Z.
Delphos, OH
8 reviews
My acne was gone overnight/reduced in size and redness so much after siding the Clean & Clear spot treatment! I found this worked best for me after I got out of the shower with a fresh face & used it before bed. I would definitely recommend to others but would be easy when applying if you have dry skin.
Kwana B.
22 reviews
Beauty Junkie Expert Level 1
This product is kinda eh I would use it if it was the last spot treatment I had. I got it from Safeway it was quite pricey there it was kinda effective.i wouldn't buy it not mix it with Persa gel and peppermint oil it will give you chemical burns. But I'm probably the only dumb person to do that. Lol
Natalie S.
fort worth, TX
21 reviews
Beauty Junkie Expert Level 2
I've been using this product for probably 2 years or so now. It's great because I'm allergic to benzoyl peroxide, and this stuff contains none. It work quickly. It was very hard to find something without benzoyl peroxide that actually worked quickly, but this is it. Plus, it doesn't smell as harsh as a lot of other acne products. And it's more gentle on the skin.
Kenna C.
102 reviews
Beauty Junkie Expert Level 4
This helps my pimples go away over night! The smell isn't too strong and it's very gentle on my skin. It gets rid of it so fast and gets rid of the redness and as far as every pimple I've had it hasn't left any scarring
lisa g.
Morehead, KY
102 reviews
Beauty Junkie Expert Level 1
this is by FAR my absolute favorite acne spot treatment!!! and that speaks volumes due to my 23 year battle with acne and even cystic acne! within minutes it seems to be working, and usually by the next morning when used at night the pimple is either gone or nearly gone! wow! need some more of this one actually. 
Chelsea J.
Paramus, NJ
17 reviews
I get the occasional pimple, once or twice a month, so I bought this because it sounded like it would help take care of my pimples quickly. But I have sensitive skin, and this product is NOT for me. It irritated my skin so much that it was red where ever I applied this product! My pimples dried up and went away, but I was left with RED, DRY, PEELING, IRRITATED skin!
Heather L.
94 reviews
This product has done nothing at all for my acne. Nothing! I've used the whole bottle now, and all the pimples are still there; it's a joke. There is literally no difference whatsoever after a month of using this. Do not buy.
Leah W.
Jackson, MS
27 reviews
Beauty Junkie Expert Level 1
i feel like this product was a hit or miss with me. I first tried this product through a friend and it worked great. When i bought it myself it didn't work as well. I used how it was directed but it just wasn't as good as the first time. I don't know if they changed the formula but the old one worked best.
Juliana D.
Harrison, NJ
20 reviews
Don't use clean and clear because it's has so much chemicals in their products . So if you want to this to rid of acne it won't help and acne will come even more. I recommend to use lush because their products have natural stuff in it , which makes your skin look clean and bright
Victoria H.
Fort Worth
170 reviews
Beauty Junkie Expert Level 4
I absolutely love this product! Put it on and in minutes you'll feel the pimple drying up, getting to the healing process. It also smells great which is always a nice price. Usually the next day its gone or at worst hardly noticeable. Love this product and recommend it to anyone who has problems with breakouts.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

Sign up to join our community!

BackInfluenster Cashback
Clean & Clear® Advantage® Acne Spot Treatment

Please confirm your email.
If you have an existing Ebates account, make sure to enter your Ebates email

6 characters minimum. Password must consist of letters, at least 1 number and 1 special character.