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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,295 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10295)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Keana B.
203 reviews
Beauty Junkie Expert Level 4
This product is really helpful in putting on bumps or acne and it gets rid of it in the next few hours or at least by the end of the day. I have never had a product like this before that works so quickly in getting rid of acne before it may leave an acne scar.
Élan B.
Kalamazoo, MI
24 reviews
Beauty Junkie Expert Level 1
This is my go-to spot treatment. I tried it for the first time about a year ago after I started breaking out before a big presentation.

It is effective and gentle and normally starts working right away. My pimples are less noticeable by the next day. I don't have to use it very often and the same tube has lasted me over a year!
Laura O.
South Gate, CA
231 reviews
Beauty Junkie Expert Level 3
I have been usin this product a long time now since middle school. For Emergency purposes only haha.. For those pimples that appear put of no where making you look weird with a red dot on your face. This is the reason why I use it, it actually works and is fast you will see the difference after a short among of applying it to your face.
Elise N.
Milwaukee, WI
99 reviews
Beauty Junkie Expert Level 3
I prefer this over the benzoyl peroxide clean & clear spot treatment because it seems to work even better and also doesn't leave a residue. I just put a bit on after I wash my face before bed and by the time I wake up, the pimple will usually be almost completely cleared up. It does seem to run out pretty fast because the tube is quite small, but it works so I continue to use it.
Breanna W.
Madison Hts, MI
43 reviews
Beauty Junkie Expert Level 2
Omg this seriously is like a gift from god lol I literally put this on my pimples every night before I sleep and yes it does burn for a couple seconds but trust me when you wake up you will see the difference I promise you that !
Cait S.
Gainesville, FL
37 reviews
Beauty Junkie Expert Level 1
I adore this product. It's been a staple in my medicine cabinet for years. It's affordable, available at basic retailers and highly effective. I only recommend using it at night because it works so quickly that it sometimes causes blemishes to come to a head. If you use it in the day, your blemish may become more noticeable because it works so quickly to push the impurities out.
Rachel G.
Savannah, GA
161 reviews
Beauty Junkie Expert Level 3
This works really well in taking care of a problem zit. It usually takes about a day or overnight to notice a difference. It helps reduce redness and dry up the zit. I would recommend having this in your arsenal. Price is worth it.
Becca M.
Orlando, FL
58 reviews
Beauty Junkie Expert Level 1
Whenever I have a zit start forming, I know I can put this on it to make it go away quickly.  This gets rid of some pimples overnight, while some do take a bit longer.  But they will always be smaller, less noticeable the next morning.  10/10 would purchase again.  I've been using the product for years.
Allyson B.
57 reviews
Beauty Junkie Expert Level 1
It worked very well with my pop up pimples but it dried my skin out. I will probably not buy this again just because my skin was flaking off. If you don’t suffer from dry skin like me then go ahead and use this product. It helped with my pimples and cleared my skin up fast. Clean & Clear® Advantage® Acne Spot Treatment
Mara W.
Blacklick, OH
195 reviews
Beauty Junkie Expert Level 4
Did a decent job on emerging acne and help keep them down without drying me out. It wasn't any different than a generic spot treatment for me but it still did its job. I believe it did help when applied to open acne to help heal.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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