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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,294 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10294)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Marissa C.
Lehi, UT
54 reviews
Beauty Junkie Expert Level 1
Best drugstore spot treatment ever made!! It's been at least 7 years that I've repurchased this clean and clear spot treatment. I've bought it over and over again because it's affordable and it works. It cleans out your pores and helps reduce redness and inflammation on skin.
Libby H.
40 reviews
Beauty Junkie Expert Level 2
I used to use the Neutrogena version of this spot treatment gel. I tried out this new gel because I really like the Clean and Clear brand. I had a large spot on my chin so I put some of this on and went to bed. The next morning it had shrunk in size and was on its way to leaving my face. I'd definitely recommend this for clearing up any pimples you might have.
Keana B.
203 reviews
Beauty Junkie Expert Level 4
This product is really helpful in putting on bumps or acne and it gets rid of it in the next few hours or at least by the end of the day. I have never had a product like this before that works so quickly in getting rid of acne before it may leave an acne scar.
Suzu W.
New York, NY
4 reviews
I first bought this product over four years ago and I've been using it ever since. Any time I see a pimple forming or I can feel it, I put the spot treatment on and the next morning there is an incredible change. I think it's worth its value because you use such a small amount each time. I love, love, love this spot treatment. 
Marissa K.
Pittsburgh, PA
4 reviews
I've been using this product for about a year now, and it's always worked really well. It reduces redness and size of blemishes overnight. However, it can dry out your skin a little bit.

Also, bonus points to this product because one bottle lasted me almost an entire year! Something I cannot say for ANY other beauty product I use.
Laura O.
South Gate, CA
231 reviews
Beauty Junkie Expert Level 3
I have been usin this product a long time now since middle school. For Emergency purposes only haha.. For those pimples that appear put of no where making you look weird with a red dot on your face. This is the reason why I use it, it actually works and is fast you will see the difference after a short among of applying it to your face.
Kira C.
Biddeford, ME
77 reviews
Although the tube looks small, a little goes a long way! It works great at drying out acne and stopping blemishes in their tracks! I also occasionally get cold sores, and this works amazing for them. It makes them dry up so quick and cuts the typical healing time for them in half. I always have a tube of this in my bathroom!
Élan B.
Kalamazoo, MI
24 reviews
Beauty Junkie Expert Level 1
This is my go-to spot treatment. I tried it for the first time about a year ago after I started breaking out before a big presentation.

It is effective and gentle and normally starts working right away. My pimples are less noticeable by the next day. I don't have to use it very often and the same tube has lasted me over a year!
Lynzi W.
Berlin, NJ
22 reviews
This is my favorite spot treatment ever. It isn't perfect, but I don't think there is any spot treatment that can get rid of a pimple in one night. This one reduces redness and size overnight. It's not the best on cystic pimples but on normal raised zits this spot treatment can make it almost disappear in about 3 uses. I've tried a lot of other spot treatments but this is by far the best
Allison B.
14 reviews
I love this product for spot clearing of my acne. I have generally clear skin but will occasionally get a deep big zit and this helps make it smaller and with a couple uses go away. It can dry out the skin though so be careful with how much repeated use you have on one spot.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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