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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,295 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10295)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Kierra B.
Mount Vernon, NY
14 reviews
Beauty Junkie Expert Level 1
If you are having a breakout this works within the first day but I wouldn’t use it past 3 days because you will start to see the parts that you put it on dry out even after the pimple is gone
Camille D.
24 reviews
Beauty Junkie Expert Level 1
I have always heard such great things about this, but it just didn’t work for me. I only bought the one tube, and after a few weeks, I noticed that it was not really helping. I have heard other people say that it didn’t work for them, it just depended. 
Ashley S.
Sacramento, CA
179 reviews
This spot treatment worked really quickly! Literally just apply the clear gel to the blemish (maybe a few times throughout the day) and it speeds up the entire process.
Keep in mind that it’s not a miracle spot treatment, the blemish just seems to go through it’s normal lifespan within a couple of days instead of lasting way longer. The blemish can still get more pronounced and/or come to a head before disappearing.
Amanda F.
94 reviews
Beauty Junkie Expert Level 4
This is my go-to product to treat those little blemishes that like to pop up each month. I want to mention that I don’t have many breakouts and if I did then I probably wouldn’t use this because it is quite drying. It’s really perfect to treat the early stages of single spot and I feel that it shortens the lifespan of each zit and even helps me avoid some of them all together!
Wendy V.
Renton, WA
120 reviews
Beauty Junkie Expert Level 3
Love this product when I have break outs on my face. I just put a small amount of product at night after my night routine and apply it on pimples. I do this two nights and my pimple is gone.
Sydney B.
Ann Arbor, MI
39 reviews
Beauty Junkie Expert Level 1
I have been using this product for years now and I have nothing bad to say about it. Whenever I get a breakout that I need to go away I will use this and put it on right before I go to bed, after using cleansers and washing away the dirt on my skin. I’ve found this to be amazing. It dries up the area making blemishes less noticeable, but not making my skin overly dry. Within 2 or 3 nights, blemishes are normally gone!! Love it
Ashlee V.
Van Buren
25 reviews
Beauty Junkie Expert Level 1
When I’m in a pinch and my face decides to break out I always get this out and just dab a little on my pimples. It works at a good rate of speed and doesn’t leave ur fave smelling funny. Clears right up and I’m on my way.
Carolyn R.
43 reviews
Beauty Junkie Expert Level 1
This is always in my medicine cabinet but I only use it in "extreme" emergencies.  Because salicylic acid is a bha it has so many interactions with other products in my skincare routine.  When I use this I have to leave out a lot of other steps.  However, it works like a charm!  When I have a particularly bad breakout I actually apply it a few times a day (I have very oily skin so I don't get dry or irritated) and it usually has decreased in size considerably by the next day.
shera s.
20 reviews
Beauty Junkie Expert Level 1
When I was a teen I tried benzoyl peroxide for my occasional acne but it irritated my skin and dried it out. So then I tried this and two decades later I still keep it on hand. I don't have a major acne problem, just the occasional pimple and this isn't magic or immediate (nothing I've seen is) but it does work well for me. A tried and true staple product.
Brooklyn R.
The Colony
13 reviews
Whenever I have a pesky zit, I apply this cream over it constantly in the morning, afternoon, and night. It really reduces the size and redness of my acne, and has many of times saved me when I had big events coming up!
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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