Woah there, it looks like your browser is out of date.

To get the best experience, please update your browser.

Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,273 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

see more...

Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10273)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Genesis A.
Wallington, NJ
100 reviews
Beauty Junkie Expert Level 4
I use this almost every time I get a new pimple coming in. Most times its still there in the morning but I think its because my hormonal acne is very challenging to get rid of. I would buy it again though because its better than any other acne medicine i have
Brittany G.
Stamford, CT
87 reviews
Beauty Junkie Expert Level 4
I've been using this stuff for years! I switch it up sometimes because it does dry out your skin and cause dry patches but otherwise if
you leave a dot of it on your acne overnight it improves by morning. If you have dry skin, be sure to use a great moisturizer. Otherwise, no complaints!
Christe L.
Pompano Beach, FL
14 reviews
I use this acne spot treatment on a daily basis even when I feel like a pimple is about to come out in a certain area I use it to help prevent it from forming. I have recommended my mom, my sisters and a bunch of my friends to try this and they all thanked me and told me it worked amazing on there skin. I would say this acne spit treatment works 100% for me, I have really dry skin and it does make my skin flake or cracked.
Karly W.
60 reviews
I bought this about two months ago and just finished it yesterday! I first want to say that this product is amazing. I place it on my pimples twice a day and the pimples are gone in 1-2 days. I have never had a product that has worked so well for acne. And the plus size is, it's around $6. I would recommend to anyone that has a problem with acne and wants it gone!
Cat S.
Sonoma, CA
52 reviews
Beauty Junkie Expert Level 2
As someone who used to have to get a prescription for my acne, I was relieved when I discovered I could use this lotion and it works! Also, drugstore prices are much better than prescription prices combined with the dermatologist. I recommend at least giving it a try!
Ashley B.
6 reviews
I have been using this spot treatment since I was in high school - about 4/5 years now! I am incredibly faithful to this product thanks to its powerful salicylic acid. I love that it's nice and light and doesn't dry out my skin, it smells good, and fast-drying! My only complaint is that it feels a little slick when you wake up in the morning. But, this stuff works!
Emily H.
Oak Creek, WI
742 reviews
This skincare product is great. It is moisturizing without being heavy or oily on my sensitive skin. It is available at many drug stores for an affordable price. It cleared acne within 3 days.
Georgina A.
Galt, CA
2 reviews
When i first bought it, i was a little skeptical of the product seeing how i have tried everything that gave no improvement. Clean & Clear did not fail to disappoint. The next day my pimple was not it's own planet anymore. It was notably smaller, less puffy, less red etc. I was amazed. One thing you do have to note is that it DOES take time, tops 2 days, for the pimple to be completely gone. You have to be patient :)
Melody S.
Coppell, TX
15 reviews
Beauty Junkie Expert Level 1
Can we all just take a moment to appreciate how inexpensive this is? (Plus it's easy to find.) And let's not also forget that this stuff really works. As in, really works, unlike a lot of other affordable acne treatments. Sometimes a new spot will pop up on my face, and all I do is apply this to it. By the end of the day (or the next morning, depending on severity), it's basically gone. Plus, it doesn't burn my skin, which a lot of other treatments do. I have no other words: This is amazing.
Brianna M.
Baltimore, MD
38 reviews
Beauty Junkie Expert Level 4
This is a great product. I feel like some breakouts its better than others but overall i still would recommend this product. It does the trick and if you catch the pimple or spot before it appears it will work. The only downfall is that i always receive a dark mark/scar from it
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

Sign up to join our community!

BackInfluenster Cashback
Clean & Clear® Advantage® Acne Spot Treatment

Please confirm your email.
If you have an existing Ebates account, make sure to enter your Ebates email

6 characters minimum. Password must consist of letters, at least 1 number and 1 special character.