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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,310 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

see more...

Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10310)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Madee M.
Jackson, MS
282 reviews
Beauty Junkie Expert Level 3
I absolute love this product. I began using it in high school and now keep it in my makeup bag at all times. It does tend to cause a little bit of a dry spot if applied repeatedly. But it does its job and it is inexpensive. I would recommend this to anyone with light to medium amounts of acne.
Brooke S.
Jersey City, NJ
67 reviews
Beauty Junkie Expert Level 4
I've been using this product for years! Anytime I feel a blemish forming, I immediately put a small amount of this on and it clears up overnight. It is a serious miracle worker! You have to be careful as it can be drying, but it's worth it to get rid of pimples.
Ella L.
32 reviews
This worked wonders i love it it is clear so you can not tell if you are wearing it if you go out it works so well i usually put it on before i sleep and my face is clean and clear after i use it i definitely recommend it. The price is great as well i will definitely buy it again.
Christina F.
331 reviews
Beauty Junkie Expert Level 3
My skin tends to respond better to salicylic acid than other active ingredients, so this is one of my favorite spot treatments. Nothing is going to make pimples disappear overnight, but this does make a noticeable difference in the size and redness.
I have noticed though that I can't use this too many nights in a row or on too large of an area, or my skin starts to get used to it and I don't see as good of a result.
Grace M.
Auburn, AL
33 reviews
Beauty Junkie Expert Level 1
I have used this for many years and i swear by it! i don't get breakouts often but when i do this is the first thing i reach for and any breakout is gone within a day or two
Missy W.
95 reviews
Beauty Junkie Expert Level 4
Like most spot treatments, I find the effectiveness to be case-by-case. And unfortunately, in my case, this one didn't do quite as well as I would have hoped. If you catch the breakout/spot when it first develops, you'll have the best luck. I noticed that it did help in slight reduction, however my skin got very irritated and dry. The pros definitely didn't outweigh the cons for me on this one.
Nathan D.
Tipton, IN
5 reviews
Beauty Junkie Expert Level 1
Besides it leaving a small, dry, flaky patch on your skin (at least for me), this product does a pretty good job of decreasing the size of a typical pimple. Salicylic acid breaks down what is blocking the pore and therefore lowers the amount of redness. It can sting a bit, especially if the pimple is opened (don't pop your zits).
Mayra Q.
Oceanside, CA
45 reviews
Beauty Junkie Expert Level 4
I've been using it for years. Every time I have a breakout or think I'm starting to have one, I apply this. I usually use it at night (apply it before bed) or in the morning (I apply it before my moisturizer). I've tried a lot of products, and a lot stop working after a few weeks (they work at first, then they just stop)... but this one has continued to work for me! And you see quick results.
Abbyyy P.
21 reviews
Beauty Junkie Expert Level 1
I normally don't breakout, but lately I've been having a breakout on my chin area that just was not going away!! I was unsure of what acne spot treatments to try out that would work best for me, I ended up choosing this one, it's super affordable, only 6$ at my local drugstore. I applied a thin layer to my problem area, it's been 24 hours and my breakout is almost gone! This worked great for me.
Taylor H.
Swarthmore, PA
87 reviews
I cant even begin to say how much I love this spot treatment. I've been using this for about over 5 years. Whenever i get an under the skin blemish I use this spot treatment, It will either bring everything to the surface (I pop it and then reuse the treatment on it and it dries up, takes about 2 days), or the under the skin blemish will disappear. I swear by the clean & clear spot treatment!
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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