Woah there, it looks like your browser is out of date.

To get the best experience, please update your browser.

Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,309 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

see more...

Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10309)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Shelly M.
Houston, TX
19 reviews
I'm at the age that I don't get a lot of pimples, but when I do get the occasional one I use Clean & Clear Advantage Acne spot treatment and it usually goes away within 24-48 hours.  I always keep a tube of this in the house.  I would recommend to anyone needing a quick spot treatment for pimples.
Adam C.
Winthrop, MA
22 reviews
This product is great, I've been meaning to purchase it again because it really did help me. I'm not giving it 5 stars because it doesn't get rid of all acne scars and some are still there but are faded as much as it can fade it. It did help with most of my scars though, and I would still recommend buying this if you have acne scars.
Andrea G.
richardson, TX
15 reviews
I've tried so many acne products including high and low end. This is probably the best drugstore acne treatment out here. I put it on overnight and when I wake up my pimple is fading. When i know I'm going to get a big pimple I put it on before it actually forms and it doesn't grow.
Bailey n.
3 reviews
I love this product! I was extremely shocked at how well this product works. This spot treatment is oil free and also has salicylic acid in it which is great for acne. You can use this product as a spot treatment or apply to the whole face. This is a drug store product so it's super affordable and worth the money! 
Mayra Q.
Oceanside, CA
45 reviews
Beauty Junkie Expert Level 4
I've been using it for years. Every time I have a breakout or think I'm starting to have one, I apply this. I usually use it at night (apply it before bed) or in the morning (I apply it before my moisturizer). I've tried a lot of products, and a lot stop working after a few weeks (they work at first, then they just stop)... but this one has continued to work for me! And you see quick results.
Madee M.
Jackson, MS
282 reviews
Beauty Junkie Expert Level 3
I absolute love this product. I began using it in high school and now keep it in my makeup bag at all times. It does tend to cause a little bit of a dry spot if applied repeatedly. But it does its job and it is inexpensive. I would recommend this to anyone with light to medium amounts of acne.
Dana L.
Liberty Twp, OH
12 reviews
This stuff is a God-send! After a tough day when I can just feel pimples popping up, I just dab this stuff on them and it is great! After 3 days it has done it's job. I think it also smells good; I would describe it as soothing. It does burn the skin a lot than other products I've used previously but it goes away after 10 minutes at the most. I wouldn't recommend this for people that don't have tough skin cause this stuff can be hard. All in all a great product!
Samantha B.
Denton, TX
25 reviews
Beauty Junkie Expert Level 1
Although it leaves my problem area VERY dry, I think it works! It's supposed to dry out the pimple and it does what it says it should.

I wouldn't recommend using makeup over this because of the dryness, but I find that if I moisturize and use the right primer then it helps!

Overall, I like this product!
Missy W.
95 reviews
Beauty Junkie Expert Level 4
Like most spot treatments, I find the effectiveness to be case-by-case. And unfortunately, in my case, this one didn't do quite as well as I would have hoped. If you catch the breakout/spot when it first develops, you'll have the best luck. I noticed that it did help in slight reduction, however my skin got very irritated and dry. The pros definitely didn't outweigh the cons for me on this one.
Ella L.
32 reviews
This worked wonders i love it it is clear so you can not tell if you are wearing it if you go out it works so well i usually put it on before i sleep and my face is clean and clear after i use it i definitely recommend it. The price is great as well i will definitely buy it again.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

Sign up to join our community!

BackInfluenster Cashback
Clean & Clear® Advantage® Acne Spot Treatment

Please confirm your email.
If you have an existing Ebates account, make sure to enter your Ebates email

6 characters minimum. Password must consist of letters, at least 1 number and 1 special character.