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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,294 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10294)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Nina C.
Madison, AL
236 reviews
Beauty Junkie Expert Level 4
I must say I am incredibly impressed so far! It really reduces the redness and I can really see my face clearing up so quickly! I'm honestly so surprised! I have sensitive and dry skin, and so it doesn't have a bit of a stinking sensation, I still think it totally works! I'm honestly surprised at how fast this works!
Kierra D.
12 reviews
I have been using this for years and one tube lasts me a long time and I love this stuff. It honestly really works and I was so skeptical because I thought if stuff like this worked then why didn't everyone use it? I have no idea why more people don't. I see a change with my pimples over night if not already gone
Katy E.
Durham, NC
39 reviews
Beauty Junkie Expert Level 1
This is hands down my go to product when I have breakouts. The formula in this product is close to magical. If I have a breakout forming, a whitehead about to pop, or an angry area with redness I take a drop the size of the tip of my finger and apply it onto the area. There is a noticeable difference within 24 hours of application. Be warned, if you apply this to an open zit it will STING!! This is a staple for anyone with any form of acne.
Lauren C.
135 reviews
Beauty Junkie Expert Level 4
This didn't work for me at all. It burned like hell when I put it on, which I assumed meant it was working, but all that ended up happening was my skin became super red and dry where I put it; on top of that, my skin peeled pretty badly at the application site. I have sensitive skin, but not THAT sensitive. The pimple/ blemishes were still there after using it, by the way, so it's not like it dried everything out, just the surface of my skin.
Taylor T.
Columbia, SC
19 reviews
This was way too much for my sensitive skin. Even though I put a tiny amount right on the blemish, the area around the blemish broke out in an irritated rash. After 1 use my skin was red, irritated, and dry for days. My skin is oily and I very rarely deal with dryness and peeling but this caused dryness and peeling.
Kasey M.
24 reviews
Beauty Junkie Expert Level 3
This has been a must-have product since I first discovered it years ago. It made sure my inflammatory acne spots were pretty non-existent by the next day. This kept me from picking at my face for stubborn spots. They were so small I didn't even worry about them being able to be covered by makeup if I needed.
Surena A.
Gainesville , GA
169 reviews
Beauty Junkie Expert Level 4
Anytime I have a blemish pop up I always reach for this. It works so fast, it is pretty much gone within a day or two! I bought mine from a Walgreens down the street, it was super inexpensive. I love the packaging because it is so small and easy to transport. I have recommended this to anyone with cystic type acne.
Nicole G.
8 reviews
This is the best drugstore product if you have a pimple/ pimples coming through. It really takes the redness away and overall shrinks the acne. I like how this product comes in a squeeze tube it makes application a lot easier. I sometimes leave this product on overnight if the breakout is a bad one. It give a nice cooling effect when you first put it on. This is something I think will always be a staple item in my collection.
Brandy G.
Chicago, IL
281 reviews
This is an excellent product. I think its a great spot treatment and it really helps get rid of a pimple or minimize one that is developing. I like to put this on before bed to specific areas. Its probably not as good for those with acne all over, but its a good product for the occasional blemish. I picked this up at Walgreens and the price is super reasonable.
Nay T.
70 reviews
It definitely works as a spot treatment, but can be drying and cause flakiness in just that spot. Would I buy it again though? Heck yes. It's great for random individual pimples but I wouldn't recommend it for overall flare-ups (in which case I'd say to use a large amount of 2.5% benzoyl peroxide gel all over)
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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