Woah there, it looks like your browser is out of date.

To get the best experience, please update your browser.

Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,330 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

see more...

Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10330)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
lexy b.
20 reviews
Beauty Junkie Expert Level 1
i bought this in a cvs and i believe it was $10 or so? this worked pretty good for my skin and i have very oily and very acne prone skin. i have this a 5 star because of the price. i believe skin care is a get what you pay for type of item most of the time and this definitely proved itself as a $10 product and maybe even a little bit more.
nicole r.
Weatherford, TX
348 reviews
Beauty Junkie Expert Level 2
Not bad product. It works fairly well. Usually resolves spot issues in a a couple days. It definitely has a very chemically feel. By that I mean you don't want to use more than you need or on skin that does not have issues. It can be a tad abrasive but girl acne sometimes calls for drastic measures!

Over all I only use it when I need a fairly quick fix. I'm in my 30's so I don't have massive break ours but I also don't like blemishes so a girl's gotta do what she has to do.
Jessica A.
Rahway, NJ
7 reviews
Beauty Junkie Expert Level 1
This stuff is amazing. I see a difference in the size of my breakouts overnight. I've been using this product for years and it never lets me down. Packaging is cute and I like that it's a squeeze-tube. I purchased it at Target, and every now and then you can find coupons for it since it's a tad pricey (but worth every penny!). Only concern would be for those who have dry skin. Definitely cannot use too much of this product or it'll dry out your skin. Highly recommend!! 
Caitlyn T.
42 reviews
Beauty Junkie Expert Level 1
really helps with drying out pimples to get rid of them. it’s a great product that i’ve been using for years. i love it and will continue to buy it and use it. really helps a lot and i would recommend it to others with acne.
Briana W.
5 reviews
This spot treatment works very well and is effective for what it is used for. You can purchase it anywhere and i would recommend it because it is gentle on the skin.
Maggie D.
9 reviews
This is a very effective product. It does what it's supposed to really - really clears up any acne that comes up. But it does have a slightly harsh smell to it, and it can sting on your face, which is why I'm giving it 4 stars out of 5. But I would use this again once my current treatment has run out (I've had this tube for almost a year and still have quite a bit left to work through)
Mariah P.
Trussville, AL
2 reviews
If you have most of the time, clear skin, with just problematic bumps or areas, this is what you need. Days when I don't wear makeup and don't wash my face, I will just apply a small amount around my nose or if I have a pimple, and when I wake up in the morning, it's practically gone. love this, but it does tend to dry out certain areas, so don't apply it all over, just on areas you need it
Lauren R.
102 reviews
Beauty Junkie Expert Level 3
I really like this medicine! I put it on after I've washed my face right before bed and when I wake up my face feels so much smoothr. The only thing is that it has somewhat of a strong smell at first but then it goes away and sometimes it burns a little when I put it on my cheeks. I have oily skin and this has ready helped me.
Tabitha K.
Port Charlotte, FL
19 reviews
I have suffered from acne for years, so given, I have tried every acne related cream, lotion, wash, and spot treatment known to man. Unfortunately, this and every other cream had little effect at all. I would used this before bed, and in the morning, It made my face look even worse! It left dark burn marks on the active spots I spot treated, and also created a few more pimples to pop up surrounding the active pimple that I put the gel on. Would not recommend.
Erin Z.
Antrim, NH
68 reviews
I love this product. It does help get rid of acne. It definitely doesn't clear your skin in just one day like the bottles says. But when you start using it more on the fresh pimples its starts working. For me i love that burning feeling when you put the product on that fresh pimples. So if you have sensitive skin i wouldn't use it.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

Sign up to join our community!

BackInfluenster Cashback
Clean & Clear® Advantage® Acne Spot Treatment

Please confirm your email.
If you have an existing Ebates account, make sure to enter your Ebates email

6 characters minimum. Password must consist of letters, at least 1 number and 1 special character.