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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,295 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10295)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Sara B.
Fresno, CA
36 reviews
Beauty Junkie Expert Level 1
I love this stuff! As soon as the blemish pops up I will put this on and overnight it is either gone completely or brought to a head. The tube lasts forever as well because you only need a tiny bit. The only part I don’t like is it will dry the spot out pretty bad so I will have to treat that with something else.
Jessica G.
San Jose, CA
51 reviews
Beauty Junkie Expert Level 1
This clean & clear spot treatment is an ok product. The packaging is nice & simple. It did not meet the expectations I was looking for. I noticed that it didn’t really help much with my big pimples. I would reaply a couple times & I didn’t see results as quickly as it can portray. The smell is also kind of weird. It the end it does work but it just takes a much later time.
Angela H.
Canyon, TX
94 reviews
Beauty Junkie Expert Level 3
This does treat acne pretty well. The only problem I have with it is it leaves the skin you put it on pretty dry. I’d honestly rather have a bit of dry skin than Mount Fuji on my face. I would highly recommend for anyone with cystic acne who has those stubborn pimples that don’t seem to be effected by normal acne treatments.
Godwin V.
18 reviews
When you apply this product to a pimple it purges the area where you applied to and this allows the pimple to grow faster before being cleared. I found that if you apply the product to an entire area it will control some of the oil production, however do not do this every day as it can irritate and dry the skin.
Madison A.
Lockport, NY
31 reviews
Beauty Junkie Expert Level 1
This spot treatment is great! I get stubborn acne sometimes but I put this on and can see a difference in just a few hours! It’s pretty much my holy grail and I even got my mom using it! So easy to apply and doesn’t dry white!
Lizzy V.
43 reviews
This acne treatment works so good on me for someone that has sensitive skin. When I apply it I feel a tingly sensation but it never hurts or burns. I use it almost everyday and it has helped gotten rid of almost all of my acne.
Christina H.
Marquette, MI
172 reviews
Beauty Junkie Expert Level 2
This little bottle is awesome! I have had it forever because a little goes a long way. Whenever I start to feel a breakout coming on, I put a dab of this on, and it goes away faster than normal.
Jessica B.
Homer Glen, IL
93 reviews
Beauty Junkie Expert Level 4
Works great for spot treatment on individual blemishes. May cause a little dryness but I would rather that over a huge pimple. This is my go to spot treatment should I notice a blemish forming.
Elyssa S.
82 reviews
Beauty Junkie Expert Level 4
I use every morning after showering. Once throughout the day. And once before bedtime. It is very drying of your skin, but as long as you’re moisturizing in between uses, you’re good. It brings my acne to the surface almost immediately, and vanishes it just as quickly. Very inexpensive. Would buy again. I keep one in my purse at all times and constantly use it on the go.
Ariana D.
Joplin, MO
40 reviews
Beauty Junkie Expert Level 1
I don't really break out much anymore but I have this on hand if I do get the occasional breakout and it is fast acting and doesn't irritate my skin. It has a medicine type smell to it but I love the smell.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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