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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,294 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

see more...

Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10294)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Liliana F.
20 reviews
It's alright... I STILL have a cluster of pimples on my chin and the contour of my cheek. I apply it every night and haven't really seen a drastic change in my skin. It sort of gets the job done, but I wouldn't say "100% of people showed clearer skin in just one day." Maybe it's just my skin type that isn't getting my the results I want (combo skin). I will, however continue to purchase this until I find something better.
Melissa L.
18 reviews
this product is a life saver! It's so effective, I just put a dab in problem areas and leave it overnight and my blemishes looks smaller and the redness is reduced. I would definitely recommend this item to anyone, it worth the price. 
Courtney H.
50 reviews
Beauty Junkie Expert Level 1
This spot treatment is really good. It reduces the size and redness of your acne. What i would do it put it on a spot that popped up right before bed after i washed my face.
Angela M.
Riviera Beach, FL
577 reviews
Beauty Junkie Expert Level 5
This is a good treatment for acne but not for an acne too severe, I felt that if it worked but as I said before, a very mild acne. Not greasy at all and I really liked it.
Jessica D.
109 reviews
This acne spot treatment is one of my holy grail products! I have repurchased this about six times now and I will continue to do so. A little goes a long way when using this product, the tube will last you two to three months. The spot treatment reduces/prevents my pimples, it diminishes my blackheads, and it fades any of my acne scars. It works so much better than the other high end products I have used. Most, if not all, of my acne is gone ever since I started using this. Definitely a must have! A little tip is to only use this twice a day because it can be drying sometimes.
Alana W.
22 reviews
Beauty Junkie Expert Level 1
I use it daily after I wash my face. After applying for multiply days you will see results. I love this product and will purchase it over and over again. A great recommendation for a cheap spot product.
Kathleen M.
Akron, OH
19 reviews
I got the whole clean and clear kit, which works amazing and smells great! I like to use it in the morning and when I go to bed! Since getting this product my skin feels smooth, clean, moisturized and my blemishes pretty much cleared over night! It also helped the discoloration of my skin from old blemishes too, which is fantastic!! I love the luxurious packaging as well! But the best thing of all is that people are asking me what I am doing to my skin (they are telling me I look younger!! Which is a major bonus as well!!)
Thank you so much Clean and Clear :D
Melanie B.
San Jose, CA
33 reviews
Beauty Junkie Expert Level 1
I think it works pretty well but nothing super special. There isn't much in the package and it doesn't last a long time. I buy it every once in a while but it's not something I need to have in my cabinet at all times.
Steffani C.
Waynesburg, PA
56 reviews
I have tried really every product on the market, so I know a thing or two about Clean & Clear. I have sensitive skin & this is one brand I can NOT use at all without getting a chemical burn or breaking out worse because it is so over-drying. I don't know what it is bc I've used other things with more salicylic acid & have not had a problem. Something is definitely wrong with their formula. I only give it a C bc I realize everyone's skin is different. But be aware about this stuff.
Christina S.
Pace, FL
263 reviews
Beauty Junkie Expert Level 4
I have been more impressed with the way this works on my skin than a Clinique spot treatment that I was using previously. Very happy to find one that actually works and is from the drugstore. It doesn't necessarily clear pimples up within a day or overnight, but it definitely speeds up the process of getting it gone. Visit my blog at christinaschiccorner.com to read my more detailed review I wrote about it in my Skincare Routine post.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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