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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,289 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10289)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Christen D.
17 reviews
Beauty Junkie Expert Level 1
Love this stuff! If i have a massive red angry pimple pop up this bad boy really gets to work and takes care of it! Redness is almost always gone by the next day.
Chelsey B.
Milledgeville, GA
788 reviews
Beauty Junkie Expert Level 5
I love using this spot treatment for a stubborn blemish that just won't go away. It works quickly and doesn't burn like other blemish products. I like to use it at night so the product sits nicely on your skin.
Adriana G.
Milwaukee, WI
29 reviews
This does help pimples come out and reduces size of pimples after a few days. It does dry out my skin if used multiple times a day. I was expecting this to work a bit quicker which is why I'm not very satisfied. The packaging is very convenient since it's a long tip you can easily dab the product on your pimple. I would also recommend just letting the gel sit on the area than smoothing it over with your finger. It seemed to work better that way. Besides that it's a great price and lasts a long time.
Niara A.
Brooklyn, NY
224 reviews
Beauty Junkie Expert Level 3
Doesn't seem to work as well as others I've used. It feels like it's doing something when you first put it on but doesn't really shorten the time of the blemish.
Heather W.
Morehead, KY
79 reviews
Beauty Junkie Expert Level 2
This actually works really well. I’ve used it when I felt a pimple coming on and it takes it away usually overnight. It does dry my skin out if I overuse it but overall works really good!
OSullivan E.
miami, FL
55 reviews
Beauty Junkie Expert Level 2
Perfect for sensitive skin.
I have been using this product for about a week now, I use it at night after I cleanse my face with their non-transparent bar. This product is really nice, I have extremely sensitive skin and am not a fan of using spot treatments because of that, but this treatment is very gentle on the skin and it reduces the redness from the acne and acne scars I have. I only use this once a day, and usually at night because that is when your skin renews itself. I find this is the best way from over drying my face and irritating it. This product gets rid of my pimples, brightens my skin, and reduces redness, so why wouldn't I want to recommend this to a friend? I love this product! :)
Rebecca A.
Scottsdale, AZ
9 reviews
Purchased this at Walgreens, works well as part of a nighttime routine. Not too harsh on surrounding skin maybe a little redness at most. Why I used it at night!
Jame G.
16 reviews
This is a great product s a must have if you have acne, i use this all the time when i get really bad acne it helps treat it fast. I really recommend this product to others. I love it
Paris D.
Arkadelphia, AR
52 reviews
Beauty Junkie Expert Level 1
You can find this product at the drug store. I find it useful for spot treating pimples/acne. I find it most effective when you put it on before bedtime, to let it sit longer.
Bre B.
Orange Park, FL
540 reviews
Words can't describe how I feel about this product! It exceeded my expectations and I will defiantly be buying this product again. I 100% recommend this product.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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