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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,274 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10274)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Jancie S.
Carson City, NV
66 reviews
Beauty Junkie Expert Level 1
I think this worked better for me when I first used it, and became less effective the more I used it. It doesn't dry my skin too much, it's inexpensive, and it works fairly well. I would recommend it.
Jasmine H.
Buford, GA
9 reviews
Beauty Junkie Expert Level 1
I found this on sale at CVS and decided to just try it out! It did what it needed to and cleared up my random pimples when I got them! It has a slight smell to it, but then again what product doesn't?
Aimee L.
12 reviews
This has always been an amazing product for me. It has either gotten rid of a spot overnight or made it considerably less noticeable. Love this product and continue to use as a backup when others fail.
Kelsey N.
Red Oak, OK
61 reviews
Beauty Junkie Expert Level 1
I don’t really feel like this does what it’s supposed too at all.. I put it in at night and wake up with my acne still looking the same! I don’t have bad acne just occasional pimples and it doesn’t seem to even help them!
Jenna H.
Beachwood, NJ
256 reviews
Beauty Junkie Expert Level 4
I get bad cystic acne. This did not really help me too much . It dried my skin but the acne was so far under my skin it really didn't help. It may help on spots closer to the skin surface. I'm not sure
Anab A.
8 reviews
If there were 10 stars thats what i would be rating it. This acne spot treatment is none like ive ever tried before. Might I remind yall ive tried proactive before it was great but the only thing to keep into your mind is that a little goes a long way and that sunscreen is KEY
Reyna A.
14 reviews
AMAZINGGGGG!!!!! I put this stuff on a pimple one night and then BAM it’s gone the next day! You have to remember to put a moisturizer on first, but don’t cake too much in it it won’t work. Apply a thin layer and you’ll be good to go!
Cassandra G.
89 reviews
Beauty Junkie Expert Level 2
I really do like this acne treatment. It really works fast. It dries out your pimples with one time of using it which is great because the packaging say to use up to three times a day. Would buy again.
Mallorie P.
Springdale, AR
328 reviews
Beauty Junkie Expert Level 3
Easy to find at your local pharmacy and not super expensive. However, doesn’t seem to do much. I didn’t notice a difference except that the skin was dry around the blemish and would peel off. Not my favorite.
Ariel L.
8 reviews
Oh my god this product is my holy grail for any pimples that's are starting to form or any acne tht has gotten too out of control. If I was able to give this product more than 5 stars I would!! The spot treatment is amazing. My mom first got me into using thisthis. This worked really well for her and she has oily acne prone skin. I'm more of a normal-dry, sensitive skin type and this works so well for me. Before I go to bed at night if I see any little buggers tht needs to be tamed I use this after my toner and before my serum. It works so well for me tht within the next morning its either gone or the swell has gone dow A LOT. If it's during the day I usually put this on before moisturzing for makeup. This has worked wonders for me and if u are thinking about buying this product I would say go for it because it's worth a try and totally worth the money if this product works for you. Happy shopping beautifuls~😀
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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