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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,328 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10328)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Sierra G.
Elko, NV
134 reviews
Beauty Junkie Expert Level 2
I have been using this product since middle school. So for 7 years or so, this product has not let me down. I use it when I don’t want to spend a lot of money on higher end products, but still need clearer skin.
Lola B.
Powder Spgs, GA
80 reviews
Beauty Junkie Expert Level 3
This is the drugstore version of the Clinique acne solutions clinical clearing gel, in my opinion. It takes a few days to clear up your pimple, but honey trust me it will!! I will say though, just to be sanitary i always use a q tip to apply this, don’t apply it from the nozzle because your pimple bacteria could get into the whole thing. Those aren’t the right words but you get what I’m saying. Definitely recommend this!
Taylor V.
27 reviews
Beauty Junkie Expert Level 1
This product is a life-saver! I’ve been using it since puberty and it is the only product that has consistently been able to quickly get rid of pimples. This is a must-have for anyone from those who have the occasional pimple to those who suffer from severe acne. I’d highly recommend it!
Jennifer P.
Williamsburg , KY
164 reviews
Beauty Junkie Expert Level 2
I loved this and also I live clean and clear it is affordable and works great I always buy their products and use this when I get blemish spots will always use their products their my favorite drugstore one
Maggie U.
Forest City, NC
28 reviews
Beauty Junkie Expert Level 1
Whenever I get a blemish this is my go to product! I go to bed with this on my face and the next morning I can see a noticeable difference. The bump has shrunk and less red and painful. This product doesn’t dry out my skin or cause any irritation! My go to product for acne spot treatment!
Kellie K.
San Jose
20 reviews
Beauty Junkie Expert Level 1
This has been my go-to for so many years, whenever I see a pimple forming, I apply this before bed to dry it out. If it needs some more help, I’ll apply it while getting ready because it’s clear, it’s undetectable. This is the only spot treatment I’ve tried, it works for me, and I’ve repurchased it so many times over the years. If there are even better product recommendations, I’d be super open to it.
Alyssa S.
Chandler, AZ
126 reviews
Beauty Junkie Expert Level 2
I liked this product for a number of reasons, the first being that it worked, and it doesn’t mess with your skin. It really just targets the blemish and destroys it. Another is that it really didn’t smell, it was light and felt good going on but didn’t leave any lingering smells which is nice.
Anneliese C.
Salem, MA
53 reviews
I’m not sure if this ever worked. Used it for about a year but never noticed an improvement. It has a strong chemical odor so I recommend jawing only at night. Can be sticky as well. Might work for some but I personally would not recommend.
Ellie B.
60 reviews
Beauty Junkie Expert Level 2
Definitely worked on my breakout spots! It took a little longer than I originally expected but it definitely worked (my reason for not giving it 5 stars) and has a bit of a chemical smell, but not too bad.
Sarah L.
Massillon, OH
58 reviews
Beauty Junkie Expert Level 3
This is my go to spot treatment for annoying acne. I use it twice a day. Normally morning and night after cleaning my face. The redness goes away quickly and the acne calms down in just 2-3 days. I love it
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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