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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,321 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

see more...

Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10321)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
sophia c.
Eugene, OR
27 reviews
Beauty Junkie Expert Level 1
this is a pretty good product. i swear by clean and clear for face products. i wasn’t disappointed. although this didn’t clear my acne completely over night, it did reduce swirling and redness. i would buy again
Shianne c.
36 reviews
Beauty Junkie Expert Level 1
I use nightly for the past month and have seen no results. The smell is very strong and chemically very over powering. It says non drying but my skin disagree. It stings when you put it on. I will not buy again.
Alexis E.
160 reviews
Beauty Junkie Expert Level 4
Love using this stuff for spot treatment. It really does quicken the time that the acne is on my face. I put it on before bed and wake up with red redness and inflammation and pain. I've been through two tubes.
Taylor B.
Poughkeepsie , NY
7 reviews
Beauty Junkie Expert Level 1
I don't usually use clean and clear or skin products with as many chemicals as them, but this spot treatment actually works unlike most I've tried. However it can feel a little harsh sometimes and stings a bit.
J R.
148 reviews
Beauty Junkie Expert Level 4
I tend to stick to mostly lush products just because of the effectiveness on my skin/breakouts. However this has always been a go to product for me when I'm in need of a spot treatment. Affordable and effective!
Hannah Q.
Bethalto, IL
57 reviews
Beauty Junkie Expert Level 2
I have been using this for as long as I can remember. I dont break out often, but when I do this is my GO TO. I apply it to my pimples usually in the morning and again at night and by the next day they are gone.
Victoria S.
46 reviews
Beauty Junkie Expert Level 1
I use this for small blemishes that arrive. It is very effective at getting rid of blemishes by the end of the week. I usually use it at night. It is a affordable option in comparison to the others on the market.
Amy D.
Lansing , IL
268 reviews
Beauty Junkie Expert Level 4
Love this on spot acne treatment! It definitely helps with my acne! When it's an open pimple it stings a little but it works! Love that I can find at any drugstore! Also very affordable! A little goes a long way!
Angelica C.
Suisun City, CA
152 reviews
Beauty Junkie Expert Level 2
I would definitely recommend if you get small break outs here and there. I like leaving it in overnight and after 2 nights I can already see a difference! No more redness and reduces the inflammation of the bump.
Ashlee G.
Helotes, TX
49 reviews
Beauty Junkie Expert Level 2
I love this acne spot treatment! Every time I feel a pimple coming on, I put some of this on it and it is noticeably smaller the next day. Very affordable and definitely worth it! 110% recommend if your looking for a good spot treatment!
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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