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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,320 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10320)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Megan O.
Woodruff, SC
35 reviews
Beauty Junkie Expert Level 1
This product is great!! I use it on my problem areas all the time! It's not expensive at all, which is nice. It doesn't hurt my face at all, I just wake up and my zit is gone or minimized! I would and still buy to this day
✨Candace D.
Deerfield Beach
3 reviews
This is the only acne medication I swear by. I can always rely on it to quickly dry out my pimples. I use the cleanser, spot treatment and moisturizing lotion. 
Nicole Z.
393 reviews
Beauty Junkie Expert Level 3
Easy to apply treatment helps with pimples that are big and growing. It stops it and helps it to heal. I use it daily whenever i feel something coming on. The odor isn’t too strong either compared to Mario Badescu drying lotion
Mitchel H.
18 reviews
Beauty Junkie Expert Level 1
This is one product that I lived by growing up, such an amazing product, I send to results after using for a week, but I had to keep using it or they would come back.
Sarah R.
Poca, WV
556 reviews
Beauty Junkie Expert Level 4
Didn’t really do anything for my acne places. Cheaper than my go to brand though. Takes some inflammation down but the texture is strange and it’s not as effective as clearasil. Good for the price but not the best acne product
carolyn k.
21 reviews
Beauty Junkie Expert Level 1
Drys put acne and gets rid it almost overnight. For those spots that pop up randomly this is what you should use. It is a bit pricy but worth it. You can find it at targetClean & Clear® Advantage® Acne Spot Treatment
Becka P.
Yukon, OK
108 reviews
Beauty Junkie Expert Level 1
I personally never saw any improvement with this product however my sister swears by it. I don't think the packaging was very nice but besides that it has a rather strong odor and just wasn't effective enough to impress me.
Las Vegas, NV
4 reviews
This spot treatment definitely does the trick. Helps my breakouts clear faster. BUT there is an expiration date (as I learned he hard way) and actually made me break out more when I accidentally used it after the expiration
Alaap M.
Philadelphia, PA
27 reviews
Beauty Junkie Expert Level 1
It really works guys! It takes a couple of nights/days but it works! It dries up the pimple and slowly makes it disappear. You may feel like it still leaves behind a mark but the mark goes away too! This is great for people who get the occasional hormonal pimple.
Melinda H.
54 reviews
Beauty Junkie Expert Level 1
This works wonders. I put it on when I see a pimple coming and the next day it's gone. This really helps when I need a pimple gone as soon as possible. I wouldn't definitely buy this again and would recommend to anyone.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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