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Clean & Clear® Advantage® Acne Spot Treatment

BY CLEAN & CLEAR #4 in Acne Treatments

4.0 out of 5 stars
  • 5 Stars46%
  • 4 Stars28%
  • 3 Stars15%
  • 2 Stars6%
  • 1 Star4%
4.05 / 5 based on 10,292 Reviews


  • The second you put it on, the powerful gel with breakthrough technology starts to dissolve surface oil on the skin.
  • With oil out of the way the clinically proven acne medicine can then penetrate pores.
  • The medication starts to clear pimples immediately, with maximum strength 2% Salicylic acid.
  • Pimples are reduced in size, swelling and redness, and the formula won’t over-dry your skin.
  • Voila! Pimple looks better. Now get out there and have some fun!

Recomended for:

Skin Need: Oil, Pimples


  • Because this is a medicine, it’s super important to start with clean skin.
  • So wash your face then apply a thin layer over your face. You can do this up to 3 times a day.
  • If your skin starts to dry out or peel, reduce your use to once a day. 


Salicylic Acid (2%)
Water SD Alcohol 40-B Hamamelis Virginiana (Witch Hazel) Water Polyacrylamide Glycerin C13-14 Isoparaffin Cyclopentasiloxane C12-15 Alkyl Lactate Alcohol Laureth-7 Phenoxyethanol Cetyl Lactate PPG-2 Isoceteth-20 Acetate Cocamidopropyl PG-Dimonium Chloride Phosphate Polysorbate 20 Phenethyl Dimethicone Fragrance Dehydroxanthan Gum Propylene Glycol Benzalkonium Chloride Ammonium Hydroxide Tetrasodium EDTA Butylene Glycol Capryloyl Glycine Sarcosine Cinnamomum Zeylanicum Bark Extract Cedrus Atlantica Bark Extract Portulaca Oleracea Extract


For external use only.
When using this product
- Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time.
- Rinse right away with water if it gets in eyes

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Top Questions See all 1,687 Q&A

  • Does this really works? my face is breaking out and I wan...1 Answers
  • Is this really helpful to people acne's or just not good ...4 Answers
  • Has anyone tried this?? Is it effective?7 Answers
Clean & Clear® Advantage® Acne Spot Treatment
Clean & Clear® Advantage® Acne Spot Treatment
Reviews (10292)
Q&A (463)
Media (121)
  • "honestly i like this prodcut and it does help get rid of pimpples but it peels your skin and leaves the area very dry and if i put makeup over it it just looks ugly but it does what it says it would" in 51 reviews
  • "this worked wonders for me but i found after a while of using it stopped working for me?im not sure if i used it too much that my skin got used to it or what but it works great it didnt dry out my skin or anything and it did what it claimed to do!" in 47 reviews
  • "I used these clean and clear product when i have a big zit..it sting when applying but the next day is gone leaving a acne mark." in 40 reviews
  • "I put some of this on after my moisturizer at night and by morning the swelling has gone down and if i reapply the pimple will go away after a day or 2." in 37 reviews
  • "This is a life saver everytime I feel a big prople coming I put this one and boom next morning its gone its soo good and cheap" in 24 reviews
Bridget B.
46 reviews
I recently decided to try this and I am really impressed. I love the shape of the bottle in that you can get a small amount out at a time. A little goes a long way. For the price it is well worth it. I use it all over my face and it has made my skin so smooth. It didn't make my skin clearer in one day like advertised on the bottle, it took about 3 days to notice a difference. however, that's still a lot better than most that I have tried. I have super sensitive skin and this product did not cause me any issues so far. For an over the counter treatment, this is definitely a good choice. I'll keep buying more in the future and would recommend it to others.
Carrie H.
Shelbyville, IN
53 reviews
I use this to zap a zit when I see it coming, it makes it go away so much quicker which helps me to not pick at it and only create scars. This is nice because it doesn’t make my face flake and peel when I use it like some other brands that I have tried.
Jessica M.
Austin, IN
81 reviews
Beauty Junkie Expert Level 2
Did an okay job. But left my skin dry and irritated. It did what it claimed to do but really did it a little to well. I have combo skin but used this during winter when my skin was dryer. I plan to try again in summer in hopes it works better!
Paige A.
Apple Valley, CA
45 reviews
Beauty Junkie Expert Level 1
It was decent. It helped the puffiness of some acne but overall didn’t really do much. The value of it was a good amount but a little to pricy for how it works. I’ve used it a few times to keep giving it chances. But nothing has changed. 
Josie J.
Pensacola, FL
72 reviews
Beauty Junkie Expert Level 1
Strong chemical smell and causes a bit of stinging on spots when you first put it on, but definitely does the job. Ive used it for a few years off and on and usually grab it when I have a stubborn breakout that i want to get rid of quickly.
Sarah D.
Santa Clara, CA
123 reviews
Beauty Junkie Expert Level 2
This product is okay, but it doesn't really do enough for me to bother. I think spot treatments generally aren't good enough for me and it is better if I focus on prevention before getting a blemish and keeping my skin hydrated if I do get one.
Mariah C.
89 reviews
Beauty Junkie Expert Level 4
This hasn’t done what it claims. I don’t notice a difference whether I use this on pimples or not. It seems slightly drier but doesn’t cause the pimples to go away any faster than just washing my face alone does. Won’t spend the money again.
Nina G.
Omaha, NE
36 reviews
I love this stuff - anytime I am getting a blemish, it takes care of it within a day or two. Definitely can use on face and body. It can dry out my skin easily if I overuse it or cover too big of an area, but if used wisely it is a godsend!
Anna S.
Oregon City , OR
106 reviews
Beauty Junkie Expert Level 1
It you're just looking for a quick easy something to grab at the drugstore this is a good product. Low cost and still gets results. I wouldn't have this for daily use but it definitely helps dry out and clear up if you have a pimple pop up.
Kathryn J.
57 reviews
Beauty Junkie Expert Level 1
I think this product definitely helps get rid of zits or blemishes but it is not very fast acting in my opinion. If I can tell I have a blemish coming in I will use this to try to prevent it from getting to the surface, which is helps with.
Cheryl T.
Gulf Shores, AL
73 reviews
Did anyone experience dryness with this product?
Jana M.
Andover, CT
60 reviews
I know you can use this as a spot treatment and just dab it on the pimples, but can you put a thin layer all over your face to prevent new ones from appearing?
Marie T.
Houston, TX
232 reviews
Beauty Junkie Expert Level 5
Is it worth the money since they're small?
Mackenzie C.
Holbrook, MA
101 reviews
Beauty Junkie Expert Level 4
Does this burn?
Blanca C.
182 reviews
Beauty Junkie Expert Level 5
Did it dry out anyone elses face where you applied it? I'm not a fan of this

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